View : 51 Download: 0

Perioperative factors associated with 1-year mortality after lung transplantation: a single-center experience in Korea

Title
Perioperative factors associated with 1-year mortality after lung transplantation: a single-center experience in Korea
Authors
Lee, Su HwanPark, Moo SukSong, Joo HanKim, Young SamLee, Jin GuPaik, Hyo ChaeKim, Song Yee
Ewha Authors
이수환
Issue Date
2017
Journal Title
JOURNAL OF THORACIC DISEASE
ISSN
2072-1439JCR Link2077-6624JCR Link
Citation
vol. 9, no. 10, pp. 4006 - 4016
Keywords
Lung transplantationmortalityrisk factorsacute kidney injury (AKI)aging
Publisher
AME PUBL CO
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: Most studies about the risk factors of 1-year mortality after lung transplantation were performed on non-Asians. This study aimed to evaluate the perioperative factors related to the 1-year mortality after lung transplantation in Korea. Methods: Sixty-eight consecutive patients who underwent lung transplantation without preoperative extracorporeal membrane oxygenation treatment at 1 tertiary hospital in South Korea between October 24, 2012, and October 16, 2015, were analyzed retrospectively. Results: Forty-four patients (64.7%) lived for >1 year after lung transplantation. The median age of all patients was 55 years (range, 16-75 years), and men accounted for 57.4%. The major cause of lung transplantation was idiopathic pulmonary fibrosis (48.5%); the other causes were interstitial lung disease related to connective tissue disease (17.6%) and bronchiolitis obliterans after stem cell transplantation (14.7%). In univariate analysis, higher median age (52 vs. 61.5 years, P<0.001), male sex (45.5% vs. 79.2%, P=0.007), lower preoperative albumin level (<3 g/dL) (22.7% vs. 45.8%, P=0.049), need for renal replacement therapy (RRT) after surgery (4.5% vs. 37.5%, P=0.001), and postoperative delta neutrophil index (DNI)>5.5 higher than the preoperative DNI (22.7% vs. 70.8%, P<0.001) were significantly related to 1-year mortality. After adjustments, old age, postoperative increased DNI, and need for RRT after transplantation were the independent perioperative risk factors for 1-year mortality after lung transplantation. Conclusions: Recipients with advanced age should be carefully selected, and patients who need RRT or with increased DNI after transplantation should be managed accordingly.
DOI
10.21037/jtd.2017.09.21
Appears in Collections:
의료원 > 의료원 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE