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Baseline Chloride Levels are Associated with the Incidence of Contrast-Associated Acute Kidney Injury

Title
Baseline Chloride Levels are Associated with the Incidence of Contrast-Associated Acute Kidney Injury
Authors
Oh H.J.Kim S.Park J.T.Kim S.-J.Han S.H.Yoo T.-H.Ryu D.-R.Kang S.-W.Chung Y.E.
Ewha Authors
류동열김상준오형중
SCOPUS Author ID
류동열scopus; 김상준scopus; 오형중scopus
Issue Date
2017
Journal Title
Scientific Reports
ISSN
2045-2322JCR Link
Citation
vol. 7, no. 1
Publisher
Nature Publishing Group
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Although hypo-And hyperchloremia have been associated with worsening renal outcomes, there has been no study that correlates hypo-And hyperchloremia and the incidence of contrast-Associated acute kidney injury (CA-AKI). A total of 13,088 patients with less than 2.0 mg/dL of serum creatinine (Cr) who underwent contrast-enhanced abdominal CT (CECT) were included. Patients were divided into 3 groups based on Cl (the hypo-, normo-And hyperchloremia groups). Patients were also classified by baseline Cr (<1.2; the 'Normal Cr group' and 1.2-2.0 mg/dL; the 'Slightly increased Cr group'). Multivariate logistic regression analysis was used to reveal the association between Cl and CA-AKI. Among patients, 2,525 (19.3%) and 241 (1.8%) patients were classified in the hypo-And hyperchloremia group. The incidence of CA-AKI was significantly lower in the normochloremia group (4.0%) compared to the hypo-(5.4%) and hyperchloremia groups (9.5%). On multivariate logistic regression, hypochloremia was significantly associated with the incidence of CA-AKI compared with normochloremia (1.382, P = 0.002). Moreover, hypochloremia was still significantly associated with the incidence of CA-AKI in 'Normal Cr group' compared with normochloremia (1.314, P = 0.015), while hyperchloremia did not show significant association with CA-AKI incidence. In conclusion, hypochloremia might be associated with the incidence of CA-AKI even in patients who have normal-range Cr levels. © 2017 The Author(s).
DOI
10.1038/s41598-017-17763-7
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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