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Caudate Volumetric Reductions Predicted by Carbohydrate-Deficient Transferrin in Patients with Alcohol Dependence

Title
Caudate Volumetric Reductions Predicted by Carbohydrate-Deficient Transferrin in Patients with Alcohol Dependence
Authors
Park S.Jung J.J.Kang I.Lee B.C.Lee S.L.Ma J.Kim J.Cho H.B.Jeong H.S.Lim S.M.Hong Y.S.Choi I.-G.Kim J.E.
Ewha Authors
홍영선임수미김지은
SCOPUS Author ID
홍영선scopus; 임수미scopus; 김지은scopus
Issue Date
2017
Journal Title
International Journal of Mental Health and Addiction
ISSN
1557-1874JCR Link
Citation
pp. 1 - 10
Keywords
Alcohol dependenceBrain volumeCarbohydrate-deficient transferrinCaudate nucleusSemi-automated segmentationStructural magnetic resonance imaging
Publisher
Springer New York LLC
Indexed
SCIE; SSCI; SCOPUS scopus
Abstract
The caudate nucleus has shown a high relevance with substance craving and addiction in the pathophysiology of alcohol dependence. In this study, caudate volumetric deficits in patients with alcohol dependence and their associations with carbohydrate-deficient transferrin (CDT), a biomarker of chronic alcohol consumption, were evaluated in 21 patients with alcohol dependence and age- and sex-matched 21 healthy comparison subjects. Between-group difference in caudate volumes and correlations between CDT and caudate volumes in the patient group were examined after adjusting for age, sex, and intracranial volume. Volumetric analysis results show prominent abnormalities in the left caudate among patients with alcohol dependence (z = − 2.70, p = 0.007). CDT levels significantly predicted volumetric deficits in the left caudate (β = − 1.23, p = 0.003). These findings suggest that the caudate nucleus may be one of the important brain regions related to alcohol-induced chronic brain damages. © 2017 Springer Science+Business Media, LLC
DOI
10.1007/s11469-017-9803-6
Appears in Collections:
의과대학 > 의학과 > Journal papers
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