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Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice with Poor Remote Memory

Title
Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice with Poor Remote Memory
Authors
Kim, HyopilKim, SomiChoi, Ja EunHan, DaeHeeKoh, Soo MinKim, Hyun-SeokKaang, Bong-Kiun
Ewha Authors
김현석
SCOPUS Author ID
김현석scopus
Issue Date
2019
Journal Title
NEUROCHEMICAL RESEARCH
ISSN
0364-3190JCR Link

1573-6903JCR Link
Citation
NEUROCHEMICAL RESEARCH vol. 44, no. 3, pp. 676 - 682
Keywords
SirtuinNeurodegenerationRemote memorySynaptic plasticity
Publisher
SPRINGER/PLENUM PUBLISHERS
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
The sirtuin family of proteins consists of nicotinamide adenine dinucleotide-dependent deacetylases that are involved in the response to calorie restriction and various physiological phenomena, such as aging and cognition. One of these proteins, sirtuin 3 (SIRT3), is localized in the mitochondria and protects the cell against oxidative or metabolic stress. Sirtuin protein deficiencies have been shown to accelerate neurodegeneration in neurotoxic conditions. The mechanisms underlying the involvement of SIRT3 in cognition remain unclear. Interestingly, SIRT1, another member of the sirtuin family, has been reported to modulate synaptic plasticity and memory formation. To learn more about these proteins, we examined the behavior and cognitive functions of Sirt3-knockout mice. The mice exhibited poor remote memory. Consistent with this, long-term potentiation was impaired in the Sirt3-knockout mice, and they exhibited decreased neuronal number in the anterior cingulate cortex, which seemed to contribute to their memory deficiencies.
DOI
10.1007/s11064-017-2417-3
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일반대학원 > 바이오융합과학과 > Journal papers
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