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Mast cells and microbiome in skin immunity

Title
Mast cells and microbiome in skin immunity
Authors
Park M.Cho K.-A.
Ewha Authors
조경아
SCOPUS Author ID
조경아scopus
Issue Date
2017
Journal Title
Journal of Bacteriology and Virology
ISSN
1598-2467JCR Link
Citation
vol. 47, no. 3, pp. 165 - 170
Keywords
Mast cellSkin homeostasisSkin immune responseSkin microbiome
Publisher
The Korean Society for Mocrobiology / The Korean Society of Virology
Indexed
SCOPUS; KCI scopus
Abstract
The skin functions as a physical barrier against entry of pathogens while concomitantly supporting a myriad of commensal organisms. The characterization of these microbial communities has enhanced our knowledge of the ecology of organisms present in normal skin, and studies have begun to illuminate the intimate relationship between the host and resident microbes. The cutaneous innate and adaptive immune responses can modulate skin microbiota, while simultaneously, the microbiota educates the host immune system. A crucial element of the innate immune response is mast cells, which reside strategically in tissues that are commonly exposed to the external environment, such as the skin and mucosae. Mast cells are present on the frontline of defense against pathogens, suggesting they may play an important role in fostering the host-microbiota relationship. In this review, we highlight findings regarding the interaction between skin microbiota and mast cells and the resulting outcomes in skin homeostasis. © 2017, The Korean Society for Mocrobiology/The Korean Society of Virology. All rights reserved.
DOI
10.4167/jbv.2017.47.3.165
Appears in Collections:
연구기관 > 의과학연구소 > Journal papers
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