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What is fetal programming?: A lifetime health is under the control of in utero health

Title
What is fetal programming?: A lifetime health is under the control of in utero health
Authors
Kwon E.J.Kim Y.J.
Ewha Authors
김영주
SCOPUS Author ID
김영주scopus
Issue Date
2017
Journal Title
Obstetrics and Gynecology Science
ISSN
2287-8572JCR Link
Citation
vol. 60, no. 6, pp. 506 - 519
Keywords
Chronic diseaseFetal developmentFetal nutrition disorders
Publisher
Korean Society of Obstetrics and Gynecology
Indexed
SCOPUS; KCI scopus
Abstract
The "Barker hypothesis" postulates that a number of organ structures and associated functions undergo programming during embryonic and fetal life, which determines the set point of physiological and metabolic responses that carry into adulthood. Hence, any stimulus or insult at a critical period of embryonic and fetal development can result in developmental adaptations that produce permanent structural, physiological and metabolic changes, thereby predisposing an individual to cardiovascular, metabolic and endocrine disease in adult life. This article will provide evidence linking these diseases to fetal undernutrition and an overview of previous studies in this area as well as current advances in understanding the mechanism and the role of the placenta in fetal programming. © 2017 Korean Society of Obstetrics and Gynecology.
DOI
10.5468/ogs.2017.60.6.506
Appears in Collections:
의과대학 > 의학과 > Journal papers
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