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Apoptosis and remodeling in adriamycin-induced cardiomyopathy rat model

Apoptosis and remodeling in adriamycin-induced cardiomyopathy rat model
Hong Y.M.Lee H.Cho M.-S.Kim K.C.
Ewha Authors
홍영미scopus; 조민선scopus; 김관창scopus
Issue Date
Journal Title
Korean Journal of Pediatrics
1738-1061JCR Link
vol. 60, no. 11, pp. 365 - 372
ApoptosisCardiomyopathiesDoxorubicinVentricular remodeling
Korean Pediatric Society
SCOPUS; KCI scopus
Purpose: The mechanism for the pathogenesis of adriamycin (ADR)-induced cardiomyopathy is not yet known. Different hypotheses include the production of free radicals, an interaction between ADR and nuclear components, and a disruption in cardiac-specific gene expression. Apoptosis has also been proposed as being involved in cardiac dysfunction. The purpose of this study was to determine if apoptosis might play a role in ADR-induced cardiomyopathy. Methods: Male Sprague-Dawley rats were separated into 2 groups: the control group (C group) and the experimental group (ADR 5 mg/wk for 3 weeks through intraperitoneal injections; A group). Echocardiographic images were obtained at week 3. Changes in caspase-3, B-cell leukemia/lymphoma (Bcl)-2, Bcl-2-associated X (Bax), interleukin (IL)-6, tumor necrosis factor-α, brain natriuretic peptide (BNP), troponin I, collagen 1, and collagen 3 protein expression from the left ventricle tissues of C and A group rats were determined by Western blot. Results: Ascites and heart failure as well as left ventricular hypertrophy were noted in the A group. Ejection fraction and shortening fraction were significantly lower in the A group by echocardiography. The expression of caspase-3, Bax, IL-6, BNP, collagen 1, and collagen 3 were significantly higher in the A group as compared with the C group. Protein expression of Bcl-2 decreased significantly in the A group compared with the C group. Conclusion: ADR induced an upregulation of caspase-3, Bax, IL-6, and collagen, as well as a depression in Bcl-2. Thus, apoptosis and fibrosis may play an important role in ADR-induced cardiomyopathy. © 2017 by The Korean Pediatric Society.
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의학전문대학원 > 의학과 > Journal papers
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