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14-3-3ζ overexpression is associated with poor prognosis in ovarian cancer

Title
14-3-3ζ overexpression is associated with poor prognosis in ovarian cancer
Authors
Kim H.-J.Sung S.H.Kim C.Y.Bae M.K.Cho M.S.Kim Y.H.Kim S.C.Ju W.
Ewha Authors
김승철조민선주웅김윤환
SCOPUS Author ID
김승철scopus; 조민선scopus; 주웅scopus; 김윤환scopus
Issue Date
2018
Journal Title
Yonsei Medical Journal
ISSN
0513-5796JCR Link
Citation
vol. 59, no. 1, pp. 51 - 56
Keywords
14-3-3ζCisplatinOvarian cancerPrognostic biomarkerRecurrence
Publisher
Yonsei University College of Medicine
Indexed
SCI; SCIE; SCOPUS; KCI scopus
Abstract
Purpose: 14-3-3ζ regulates cell signaling, cell cycle progression, and apoptosis, and its overexpression is associated with disease recurrence and poor clinical outcomes in some solid tumors. However, its clinicopathological role in ovarian cancer is unknown. Our goal was to investigate whether 14-3-3ζ is associated with ovarian cancer prognosis. Materials and Methods: We examined 14-3-3ζ expression by immunohistochemistry in ovarian cancer tissues obtained from 88 ovarian cancer patients. The examined tissues were of various histologies and stages. 14-3-3ζ expression was also analyzed by western blot in seven ovarian cancer cell lines and a primary ovary epithelial cell line. Cell viability was measured using an MTS-based assay following cisplatin treatment. Results: Among the ovarian cancer samples, 53.4% (47/88) showed high 14-3-3ζ expression, and 14-3-3ζ overexpression was positively correlated with more advanced pathologic stages and grades. 14-3-3ζ overexpression was also significantly associated with poor disease-free survival (DFS) and overall survival (OS) of ovarian cancer patients. Median DFS and OS were 1088 and 3905 days, respectively, in the high 14-3-3ζ expression group, but not reached in the low 14-3-3ζ expression group (p=0.004 and p=0.033, log-rank test, respectively). Downregulating 14-3-3ζ by RNA interference in ovarian cancer cells led to enhanced sensitivity to cisplatin-induced cell death. Conclusion: 14-3-3ζ overexpression might be a potential prognostic biomarker for ovarian cancer, and the inhibition of 14-3-3ζ could be a therapeutic option that enhances the antitumor activity of cisplatin. © Yonsei University College of Medicine 2018.
DOI
10.3349/ymj.2018.59.1.51
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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