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The effect of reproductive factors on breast cancer presentation in women who are BRCA mutation carrier

Title
The effect of reproductive factors on breast cancer presentation in women who are BRCA mutation carrier
Authors
Kim J.-Y.Moon H.-G.Kang Y.-J.Han W.Noh W.-C.Jung Y.Moon B.-I.Kang E.Park S.-S.Lee M.H.Park B.Y.Lee J.W.Noh D.-Y.
Ewha Authors
문병인
SCOPUS Author ID
문병인scopus
Issue Date
2017
Journal Title
Journal of Breast Cancer
ISSN
1738-6756JCR Link
Citation
vol. 20, no. 3, pp. 279 - 285
Keywords
BRCA1 genesBRCA2 genesBreast neoplasmsReproductive history
Publisher
Korean Breast Cancer Society
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Purpose: Germline mutations in the BRCA1 and BRCA2 genes confer increased risks for breast cancers. However, the clinical presentation of breast cancer among women who are carriers of the BRCA1 or BRCA2 (BRCA1/2 carriers) mutations is heterogenous. We aimed to identify the effects of the reproductive histories of women with the BRCA1/2 mutations on the clinical presentation of breast cancer. Methods: We retrospectively analyzed clinical data on women with proven BRCA1 and BRCA2 mutations who were recruited to the Korean Hereditary Breast Cancer study, from 2007 to 2014. Results: Among the 736 women who were BRCA1/2 mutation carriers, a total of 483 women had breast cancers. Breast cancer diagnosis occurred at significantly younger ages in women who experienced menarche at ≤ 14 years of age, compared to those who experienced menarche at > 14 years of age (37.38±7.60 and 43.30±10.11, respectively, p< 0.001). Additionally, the number of full-term pregnancies was significantly associated with the age of diagnosis, especially in women with the BRCA2 mutation. The prevalence of advanced stages (stage II or III vs. stage I) of disease in parous women was higher than in nulliparous women (68.5% vs. 55.2%, p= 0.043). This association was more pronounced in women with the BRCA2 mutation (hazard ratio, 2.67; p= 0.014). Conclusion: Our results suggest that reproductive factors, such as the age of onset of menarche and the presence of parity, are associated with the clinical presentation patterns of breast cancer in BRCA1/2 mutation carriers. © 2017 Korean Breast Cancer Society. All rights reserved.
DOI
10.4048/jbc.2017.20.3.279
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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