View : 114 Download: 22

Current immunotherapeutic strategies in hepatocellular carcinoma: Recent advances and future directions

Title
Current immunotherapeutic strategies in hepatocellular carcinoma: Recent advances and future directions
Authors
Kim H.Y.Park J.-W.
Ewha Authors
김희영김휘영
SCOPUS Author ID
김휘영scopus
Issue Date
2017
Journal Title
Therapeutic Advances in Gastroenterology
ISSN
1756-283XJCR Link
Citation
vol. 10, no. 10, pp. 805 - 814
Keywords
clinical trialhepatocellular carcinomaimmunotherapy
Publisher
SAGE Publications Ltd
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Hepatocellular carcinoma (HCC) is a common and serious health problem with high mortality. Treatment for HCC remains largely unsatisfactory owing to its high recurrence rates and frequent accompanying cirrhosis. In addition, the unique immune environment of the liver promotes tolerance, which, in conjunction with immune evasion by the disease, makes HCC a less promising target for conventional immunotherapy. However, recent advances in the immunotherapy have led to novel approaches to overcome these obstacles by manipulating and enhancing tumor-specific immune responses against HCC by using various modalities, such as cancer vaccines and immune checkpoint blockade. These treatments have shown both safety and promising outcomes in patients with HCC of various etiologies and tumor stages. Furthermore, combined strategies have been assessed to achieve optimal outcomes, by using immunotherapies with or without conventional treatments. This review briefly covers the background, recent advances, current issues, and future perspectives on immunotherapy in the field of HCC treatment. © SAGE Publications.
DOI
10.1177/1756283X17722061
Appears in Collections:
연구기관 > 의과학연구소 > Journal papers
Files in This Item:
Current immunotherapeutic.pdf(249.37 kB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE