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Incidence, mortality, and causes of death in physician-diagnosed primary Sjögren's syndrome in Korea: A nationwide, population-based study

Title
Incidence, mortality, and causes of death in physician-diagnosed primary Sjögren's syndrome in Korea: A nationwide, population-based study
Authors
Kim H.J.Kim K.H.Hann H.J.Han S.Kim Y.Lee S.H.Kim D.S.Ahn H.S.
Ewha Authors
한후재
SCOPUS Author ID
한후재scopus
Issue Date
2017
Journal Title
Seminars in Arthritis and Rheumatism
ISSN
0049-0172JCR Link
Citation
vol. 47, no. 2, pp. 222 - 227
Keywords
Causes of deathEpidemiologyMortalityPrimary Sjögren'ssyndrome
Publisher
W.B. Saunders
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objectives The objective of this study was to investigate the epidemiological features of primary Sjögren's syndrome (pSS) in Korea at a national level, including the incidence, mortality, and causes of death. Methods We used a national, population-based registry database called the Rare Intractable Disease Registration Program from the Health Insurance Review and Assessment Service to obtain pSS patient data for the period between 2010 and 2014. pSS was diagnosed by a physician based on uniform criteria. We also used data from Statistics Korea to confirm the mortality and causes of death. Results Between 2010 and 2014, the total number of patients newly diagnosed with pSS was 5891, resulting in an annual incidence of 2.34 per 100,000 individuals. The female-to-male ratio was 14.5:1. A total of 114 pSS patients died during the study period. The overall survival rate of pSS patients was 99.0%, and the 1-year, 2-year, and 5-year survival rates were 98.7%, 98.1%, and 97.1%, respectively, and the standardized mortality ratio (SMR) was 1.47 (2.14 for males and 1.35 for females). The most common causes of death were respiratory disease (n = 25; 21.9%) followed by circulatory diseases (n = 21; 18.4%), musculoskeletal connective tissue diseases (n = 21; 18.4%), and cancer (n=19; 16.7%). Conclusions The national incidence of pSS in Korea presented in this study was lower in comparison with reports from other countries. However, the mortality rate was significantly higher than the corresponding values in the age- and gender-matched general population. The higher mortality in pSS patients is attributable to respiratory diseases and lung cancer. © 2017 Elsevier Inc.
DOI
10.1016/j.semarthrit.2017.03.004
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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