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Prognostic Value of Percentage Change in Metabolic Parameters as Measured by Dual-Time Point 18F-FDG PET/CT in Premenopausal Women with Invasive Ductal Breast Carcinoma

Title
Prognostic Value of Percentage Change in Metabolic Parameters as Measured by Dual-Time Point 18F-FDG PET/CT in Premenopausal Women with Invasive Ductal Breast Carcinoma
Authors
Yoo J.Yoon H.-J.Kim B.S.
Ewha Authors
김범산윤혜전
SCOPUS Author ID
김범산scopus; 윤혜전scopus
Issue Date
2017
Journal Title
Journal of Women's Health
ISSN
1540-9996JCR Link
Citation
vol. 26, no. 10, pp. 1131 - 1137
Keywords
dual time point 18F-FDG PET/CTinvasive ductal breast carcinomametabolic tumor volumeprognosisrecurrence-free survival
Publisher
Mary Ann Liebert Inc.
Indexed
SCI; SCIE; SSCI; SCOPUS WOS scopus
Abstract
Objectives: We retrospectively evaluated the prognostic significance of dual-time point (DTP) 18F-FDG positron emission tomography/computed tomography (PET/CT) parameters compared with clinicopathological findings in premenopausal women with invasive ductal breast carcinoma (IDC). Materials and Methods: Sixty-six premenopausal women (mean age: 42.7 ± 5.6, range: 29.5-51.8 years) who had pathologically confirmed IDC were enrolled. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured and used to calculate percentage changes over the DTP time interval. We analyzed the prognostic significance of DTP PET/CT parameters, clinicopathological factors of pathologic tumor diameter (pTD), axillary lymph node status (ANS), nuclear grade, histologic grade, and immunohistochemistry findings using univariate and multivariate analyses. Results: Disease recurrence was observed in 22 patients. In univariate analysis, SUVmax > 7.39, MTV > 4.28, TLG > 52.38, %ΔSUVmax > 20.44, %ΔTLG >-13.86, pTD > 2.8 cm, positive ANS, estrogen receptor (ER) negativity, and triple negativity were associated with worse prognosis than those of opposite groups in recurrence-free survival (all p < 0.05). %ΔSUVmax (>20.44, p = 0.0042), TLG (>52.38, p = 0.0002), and ER negativity (p = 0.0003) were independent prognostic variables after multivariate analysis. Conclusion: Percentage changes in SUVmax using DTP PET/CT and TLG were significant independent prognostic factors of disease recurrence along with ER negativity in premenopausal women with IDC. © 2017, Mary Ann Liebert, Inc.
DOI
10.1089/jwh.2016.6256
Appears in Collections:
의과대학 > 의학과 > Journal papers
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