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Low Skeletal Muscle Mass is Associated with the Risk of Low Bone Mineral Density in Urban Dwelling Premenopausal Women

Title
Low Skeletal Muscle Mass is Associated with the Risk of Low Bone Mineral Density in Urban Dwelling Premenopausal Women
Authors
Kim I.J.Kang K.Y.
Ewha Authors
김인제
SCOPUS Author ID
김인제scopus
Issue Date
2017
Journal Title
Calcified Tissue International
ISSN
0171-967XJCR Link
Citation
vol. 101, no. 6, pp. 581 - 592
Keywords
Bone mineral densityPremenopausal womenSkeletal muscle massUrban
Publisher
Springer New York LLC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
To evaluate the relationship between skeletal muscle mass and bone mineral density (BMD) and to determine the association between low skeletal muscle mass and low BMD in urban dwelling young adults. This study was based on data from the 2008–2011 Korea National Health and Nutrition Examination Surveys. The subjects were 1702 20–49-year-old men and 2192 premenopausal women (age 20–55 years). BMD at the lumbar spine, femoral neck, and total hip and the appendicular skeletal muscle mass (ASM) were measured by dual-energy X-ray absorptiometry. Skeletal muscle mass index (SMI) was defined as weight-adjusted ASM. Mildly and severely low muscle skeletal mass were defined as SMI that was 1–2 and >2 standard deviations below the sex-specific mean ASM of young adults, respectively. Low BMD was defined as T score of less than −1.0 at the lumbar spine, femoral neck, and/or total hip. After adjusting for confounders, skeletal muscle mass was positively associated with BMD at the lumbar spine, femoral neck, and total hip in both men and women. Mildly and severely low skeletal muscle mass increased the risk of low BMD in premenopausal women [OR (95% CI) = 1.4 (1.1–1.9) and 2.4 (1.2–4.6), respectively] but not men. In women, low skeletal muscle mass independently was associated with the risk of low BMD at the femoral neck and total hip but not the lumbar spine. Skeletal muscle mass was independently associated with BMD in urban dwelling young men and women, but low skeletal muscle mass was associated with the risk of low BMD in premenopausal women only. © 2017, Springer Science+Business Media, LLC.
DOI
10.1007/s00223-017-0314-z
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의료원 > 의료원 > Journal papers
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