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Efficient reporting of the estimated glomerular filtration rate without height in pediatric patients with cancer

Title
Efficient reporting of the estimated glomerular filtration rate without height in pediatric patients with cancer
Authors
Jeong T.-D.Cho E.-J.Lee W.Chun S.Hong K.-S.Min W.-K.
Ewha Authors
홍기숙정태동
SCOPUS Author ID
홍기숙scopus; 정태동scopus
Issue Date
2017
Journal Title
Clinical Chemistry and Laboratory Medicine
ISSN
1434-6621JCR Link
Citation
vol. 55, no. 12, pp. 1891 - 1897
Keywords
childrencreatinineglomerular filtration rateheightlaboratory information system
Publisher
Walter de Gruyter GmbH
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The updated bedside Schwartz equation requires constant, serum creatinine concentration and height measurements to calculate the estimated glomerular filtration rate (eGFR) in pediatric patients. Unlike the serum creatinine levels, obtaining height information from the laboratory information system (LIS) is not always possible in a clinical laboratory. Recently, the height-independent eGFR equation, the full age spectrum (FAS) equation, has been introduced. We evaluated the performance of height-independent eGFR equation in Korean children with cancer. A total of 250 children who underwent chromium-51-ethylenediamine tetra acetic-acid (51Cr-EDTA)-based glomerular filtration rate (GFR) measurements were enrolled. The 51Cr-EDTA GFR was used as the reference GFR. The bias (eGFR - measured GFR), precision (root mean square error [RMSE]) and accuracy (P30) of the FAS equations were compared to those of the updated Schwartz equation. P30 was defined as the percentage of patients whose eGFR was within ±30% of the measured GFR. The FAS equation showed significantly lower bias (mL/min/1.73 m2) than the updated Schwartz equation (4.2 vs. 8.7, p<0.001). The RMSE and P30 were: updated Schwartz of 43.8 and 64.4%, respectively, and FAS of 42.7 and 66.8%, respectively. The height-independent eGFR-FAS equation was less biased and as accurate as the updated Schwartz equation in Korean children. The use of the height-independent eGFR equation will allow for efficient reporting of eGFR through the LIS in clinical laboratories. © 2017 Walter de Gruyter GmbH, Berlin/Boston.
DOI
10.1515/cclm-2016-1151
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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