View : 19 Download: 0

Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma

Title
Improved prognostic stratification using NCCN- and GELTAMO-international prognostic index in patients with diffuse large B-cell lymphoma
Authors
Hong, JunshikKim, Seok JinChang, Myung HeeKim, Jeong-AKwak, Jae-YongKim, Jin SeokYoon, Dok HyunLee, Won SikDo, Young RokKang, Hye JinEom, Hyeon-SeokPark, YongWon, Jong-HoMun, Yeung-ChulKim, Hyo JungKwon, Jung HyeKong, Jee HyunOh, Sung YongLee, SunahBae, Sung HwaYang, Deok-HwanJun, Hyun JungLee, Ho SupYun, Hwan JungLee, Soon IlKim, Min KyoungYi, Jun HoLee, Jae HoonKim, Won SeogSuh, Cheolwon
Ewha Authors
문영철
SCOPUS Author ID
문영철scopus
Issue Date
2017
Journal Title
ONCOTARGET
ISSN
1949-2553JCR Link
Citation
vol. 8, no. 54, pp. 92171 - 92182
Keywords
non-hodgkin lymphomadiffuse large B-cell lymphomainternational prognostic indexprognosisoverall survival
Publisher
IMPACT JOURNALS LLC
Indexed
SCIE; SCOPUS WOS
Abstract
The National Comprehensive Cancer Network (NCCN)-International Prognostic Index (IPI) and GELTAMO (Grupo Espanol de Linfomas/Trasplante Autologo de Medula Osea)-IPI were developed to enable better risk prediction of patients with diffuse large B-cell lymphoma (DLBCL). The present study compared the effectiveness of risk prediction between IPI, NCCN-IPI, and GELTAMO-IPI in patients with DLBCL particularly in terms of determining high-risk patients. Among 439 patients who were enrolled to a prospective DLBCL cohort treated with R-CHOP immunochemotherapy, risk groups were classified according to the three IPIs and the prognostic significance of individual IPI factors and IPI models were analyzed and compared. All three IPI effectively separated the analyzed patients into four risk groups according to overall survival (OS). Estimated 5-year OS of patients classified as high-risk according to the IPI was 45.7%, suggesting that the IPI is limited in the selection of patients who are expected to have a poor outcome. In contrast, the 5-year OS of patients stratified as high-risk according to NCCN- and GELTAMO-IPI was 31.4% and 21.9%, respectively. The results indicate that NCCN- and GELTAMO-IPI are better than the IPI in predicting patients with poor prognosis, suggesting the superiority of enhanced, next-generation IPIs for DLBCL.
DOI
10.18632/oncotarget.20988
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
Improved prognostic stratification.pdf(1.72 MB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE