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Salvage radiotherapy for locoregionally recurrent extrahepatic bile duct cancer after radical surgery
- Salvage radiotherapy for locoregionally recurrent extrahepatic bile duct cancer after radical surgery
- Kim, Eunji; Kim, Yi-Jun; Kim, Kyubo; Song, Changhoon; Kim, Jae-Sung; Oh, Do-Youn; Nam, Eun Mi; Chie, Eui Kyu
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- BRITISH JOURNAL OF RADIOLOGY
- 0007-1285; 1748-880X
- vol. 90, no. 1080
- BRITISH INST RADIOLOGY
- SCI; SCIE; SCOPUS
- Objective: This study evaluated the outcome of salvage radiotherapy for locoregionally recurrent extrahepatic bile duct cancer. Methods: We performed a retrospective review of 23 extrahepatic bile duct cancer patients who underwent radiotherapy with or without concomitant chemotherapy for isolated locoregional recurrence after radical surgery between August 2001 and September 2013. The median disease-free interval was 11.8 months. Salvage radiotherapy was delivered to the recurrent tumour with or without initial operation bed up to a median dose of 54 Gy (range, 45-60). 18 patients received concomitant chemotherapy. Results: The median follow-up period was 14.2 months for all patients, and 48.8 months for survivors. The median overall survival and progression-free survival (PFS) were 18.4 (range, 4.4-114.6) and 15.5 months (range, 1.6-114.6), respectively. On multivariate analysis, the use of concomitant chemotherapy was a favourable prognostic factor for PFS (p = 0.027), and prolonged disease- free interval (>= 1 year) was associated with a significantly poor overall survival ( p = 0.047). Grade 3 or higher toxicities did not occur in follow-up period. Conclusion: Salvage radiotherapy showed promising survival outcomes in locoregional recurrence of extrahepatic bile duct cancer. Our results indicated that concomitant chemotherapy was associated with improved PFS. Concurrent chemoradiotherapy can be a viable salvage treatment option in selected patients.
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