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Recent advances in the synthesis of the carbocyclic nucleosides as potential antiviral agents
- Recent advances in the synthesis of the carbocyclic nucleosides as potential antiviral agents
- Jeong L.S.; Lee J.A.
- Ewha Authors
- Issue Date
- Journal Title
- Antiviral Chemistry and Chemotherapy
- vol. 15, no. 5, pp. 235 - 250
- Compared with 4′-oxonucleosides, there have been far fewer systematic structure-activity relationship studies on carbocyclic nucleosides as antiviral and antitumour agents. This is mainly because of the synthetic problems in preparing the carbasugars. However, the recent discovery of the ring-closing metathesis (RCM) (a powerful tool for the preparation of 5-membered carbasugar via C-C bond formation) has made it possible to synthesize the key carbasugars to a preparative scale. This review summarizes the asymmetric syntheses of carbasugars and carbocyclic nucleosides, using an RCM reaction as a key step. Furthermore, the review includes valuable information for designing and synthesizing novel carbocyclic nucleosides.
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