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Recent advances in the synthesis of the carbocyclic nucleosides as potential antiviral agents

Title
Recent advances in the synthesis of the carbocyclic nucleosides as potential antiviral agents
Authors
Jeong L.S.Lee J.A.
Ewha Authors
정낙신
Issue Date
2004
Journal Title
Antiviral Chemistry and Chemotherapy
ISSN
0956-3202JCR Link
Citation
vol. 15, no. 5, pp. 235 - 250
Indexed
SCOPUS scopus
Abstract
Compared with 4′-oxonucleosides, there have been far fewer systematic structure-activity relationship studies on carbocyclic nucleosides as antiviral and antitumour agents. This is mainly because of the synthetic problems in preparing the carbasugars. However, the recent discovery of the ring-closing metathesis (RCM) (a powerful tool for the preparation of 5-membered carbasugar via C-C bond formation) has made it possible to synthesize the key carbasugars to a preparative scale. This review summarizes the asymmetric syntheses of carbasugars and carbocyclic nucleosides, using an RCM reaction as a key step. Furthermore, the review includes valuable information for designing and synthesizing novel carbocyclic nucleosides.
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약학대학 > 약학과 > Journal papers
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