Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서영주 | - |
dc.date.accessioned | 2017-11-22T06:30:02Z | - |
dc.date.available | 2017-11-22T06:30:02Z | - |
dc.date.issued | 2007 | - |
dc.identifier.isbn | 9781860947834 | - |
dc.identifier.issn | 1751-6404 | - |
dc.identifier.other | OAK-18198 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/239193 | - |
dc.description.abstract | We study in detail a particular statistical method in genetic case-control analysis, labeled "genotypebased association", in which the two test results from assuming dominant and recessive model are combined in one optimal output. This method differs both from the allele-based association which artificially doubles the sample size, and the direct χ 2 test on 3-by-2 contingency table which may overestimate the degree of freedom. We conclude that the comparative advantage (or disadvantage) of the genotype-based test over the allele-based test mainly depends on two parameters, the allele frequency difference δ and the Hardy-Weinberg disequilibrium coefficient difference δo. Six different situations, called "phases", characterized by the two χ 2 test statistics in allele-based and genotypebased test, are well separated in the phase diagram parameterized by δ and δ ε. For two major groups of phases, a single parameter θ = tan -1(δ/δε) is able to achieves an almost perfect phase separation. We also applied the analytic result to several types of disease models. It is shown that for dominant and additive models, genotype-based tests are favored over allele-based tests. | - |
dc.language | English | - |
dc.title | Genotype-based case-control analysis, violation of Hardy-Weinberg equilibrium, and phase diagrams | - |
dc.type | Conference Paper | - |
dc.relation.volume | 5 | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 185 | - |
dc.relation.lastpage | 194 | - |
dc.relation.journaltitle | Series on Advances in Bioinformatics and Computational Biology | - |
dc.identifier.scopusid | 2-s2.0-84863025872 | - |
dc.author.google | Suh Y.J. | - |
dc.author.google | Li W. | - |
dc.date.modifydate | 20180608120420 | - |