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Atypical cerebral manifestations of disseminated Mycobacterium tuberculosis

Title
Atypical cerebral manifestations of disseminated Mycobacterium tuberculosis
Authors
Hwang J.H.Lee K.M.Park J.E.Kim H.-G.Kim E.J.Choi W.S.Yang N.R.
Ewha Authors
양나래
SCOPUS Author ID
양나래scopus
Issue Date
2017
Journal Title
Frontiers in Neurology
ISSN
1664-2295JCR Link
Citation
vol. 8, no. SEP
Keywords
Atypical tuberculosis meningitisDisseminated tuberculosisPost-contrast fluid-attenuated inversion recoveryTuberculomaTuberculous meningitis
Publisher
Frontiers Media S.A.
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: We investigated the patterns of cerebral manifestations in patients with underlying pulmonary or extrapulmonary tuberculosis or disseminated tuberculosis. Materials and methods: From January 2010 to September 2016, brain magnetic resonance imaging (MRI) scans were obtained to evaluate cerebral manifestations in patients with underlying pulmonary or extrapulmonary tuberculosis. We also included patients with drug-resistant tuberculosis or disseminated tuberculosis. MRI findings of tuberculous meningitis and tuberculoma were classified as typical; other MRI findings were classified as atypical. Demographic data, risk factors, and drug regimens were collected and analyzed. Results: Twenty-two patients were diagnosed with cerebral tuberculosis. Cerebral tuberculosis was due to hematogenous spread from pulmonary tuberculosis (10 patients), spinal tuberculosis (8 patients), disseminated tuberculosis (3 patients), and unknown causes (1 patient). There were six patients with typical MRI findings (three patients with typical meningitis involving the basal cistern and supratentorium, one patient with tuberculomas, and two patients with both) and seven patients with atypical MRI findings [five patients with evidence of early meningitis, such as high signal intensity on fluid-attenuated inversion recovery (FLAIR) along the cerebellar folia, and two patients with only hydrocephalus]. Conclusion: Besides the typical sites of meningeal involvement, overlooked findings such as FLAIR abnormalities along the cerebellar folia or hydrocephalus should be checked for early detection of cerebral tuberculosis and initiation of the appropriate treatment against disseminated tuberculosis. © 2017 Hwang, Lee, Park, Kim, Kim, Choi and Yang.
DOI
10.3389/fneur.2017.00462
Appears in Collections:
의료원 > 의료원 > Journal papers
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