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약학대학
약학과
Journal papers
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miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation
Title
miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation
Authors
Ban Y.H.
;
Oh S.-C.
;
Seo S.-H.
;
Kim S.-M.
;
Choi I.-P.
;
Greenberg P.D.
;
Chang J.
;
Kim T.-D.
;
Ha S.-J.
Ewha Authors
장준
SCOPUS Author ID
장준
Issue Date
2017
Journal Title
Cell Reports
ISSN
2211-1247
Citation
Cell Reports vol. 20, no. 11, pp. 2598 - 2611
Keywords
acute
;
CD8
;
differentiation
;
Foxo1
;
infection
;
LCMV
;
memory
;
miR-150
;
primary immune response
;
recall
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
MicroRNA (miR)-150 is a developmental regulator of several immune-cell types, but its role in CD8+ T cells is largely unexplored. Here, we show that miR-150 regulates the generation of memory CD8+ T cells. After acute virus infection, miR-150 knockout (KO) mice exhibited an accelerated differentiation of CD8+ T cells into memory cells and improved production of effector cytokines. Additionally, miR-150 KO CD8+ T cells displayed an enhanced recall response and improved protection against infections with another virus and bacteria. We found that forkhead box O1 (Foxo1) and T cell-specific transcription factor 1 (TCF1) are upregulated during the early activation phase in miR-150 KO CD8+ T cells and that miR-150 directly targets and suppresses Foxo1. These results suggest that miR-150-mediated suppression of Foxo1 regulates the balance between effector and memory cell differentiation, which might aid in the development of improved vaccines and T cell therapeutics. © 2017 The Authors
DOI
10.1016/j.celrep.2017.08.065
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