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miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation

Title
miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation
Authors
Ban Y.H.Oh S.-C.Seo S.-H.Kim S.-M.Choi I.-P.Greenberg P.D.Chang J.Kim T.-D.Ha S.-J.
Ewha Authors
장준
SCOPUS Author ID
장준scopus
Issue Date
2017
Journal Title
Cell Reports
ISSN
2211-1247JCR Link
Citation
vol. 20, no. 11, pp. 2598 - 2611
Keywords
acuteCD8differentiationFoxo1infectionLCMVmemorymiR-150primary immune responserecall
Indexed
SCIE; SCOPUS WOS scopus
Abstract
MicroRNA (miR)-150 is a developmental regulator of several immune-cell types, but its role in CD8+ T cells is largely unexplored. Here, we show that miR-150 regulates the generation of memory CD8+ T cells. After acute virus infection, miR-150 knockout (KO) mice exhibited an accelerated differentiation of CD8+ T cells into memory cells and improved production of effector cytokines. Additionally, miR-150 KO CD8+ T cells displayed an enhanced recall response and improved protection against infections with another virus and bacteria. We found that forkhead box O1 (Foxo1) and T cell-specific transcription factor 1 (TCF1) are upregulated during the early activation phase in miR-150 KO CD8+ T cells and that miR-150 directly targets and suppresses Foxo1. These results suggest that miR-150-mediated suppression of Foxo1 regulates the balance between effector and memory cell differentiation, which might aid in the development of improved vaccines and T cell therapeutics. © 2017 The Authors
DOI
10.1016/j.celrep.2017.08.065
Appears in Collections:
약학대학 > 약학과 > Journal papers
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