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Influence of growth hormone treatment on radiographic indices of the spine: Propensity-matched analysis

Title
Influence of growth hormone treatment on radiographic indices of the spine: Propensity-matched analysis
Authors
Yun Y.-H.Kwon S.-S.Koh Y.Kim D.-J.Ahn J.Lee S.Y.
Ewha Authors
고영도
SCOPUS Author ID
고영도scopus
Issue Date
2017
Journal Title
Journal of Orthopaedic Surgery and Research
ISSN
1749-799XJCR Link
Citation
vol. 12, no. 1
Keywords
Growth hormonePropensity-matched analysisScoliosis
Publisher
BioMed Central Ltd.
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: We performed this study to investigate the influence of recombinant human growth hormone (rhGH) therapy on radiographic indices of the spine using propensity-matched analysis. Methods: Patients with idiopathic short stature who had undergone both growth hormone therapy and whole-spine radiographs more than twice prior to 15years of age were included in the patient group. Other patients who had undergone whole-spine radiographs more than twice prior to the same age during regular checkups for idiopathic scoliosis formed the control group. Propensity-matched analysis was performed to reduce the selection bias. The scoliosis Cobb angle, coronal balance, apical vertebral translation, apical rotation, and pelvic obliquity were measured from the radiographs taken at the periodic follow-ups. The rate of progression of the measurements was adjusted by multiple factors using a linear mixed model with sex as the fixed effect and age and each subject as the random effects. Results: Using a propensity-matched analysis, 48 patients were finally included in both groups. The scoliosis Cobb angle increased by 1.0° (p<0.001) per year in the patient group, whereas there was no significant annual change in the control group (p=0.496). Female patients showed a greater scoliosis Cobb angle (1.8°, p=0.039) compared with male patients. There was no significant difference between the patient and control groups in coronal balance (p=0.264). Apical vertebral translation per year was increased by 1.2mm (p<0.001) in the patient group and 0.5mm in the control group (p=0.003). Conclusion: Radiographic examination revealed that growth hormone therapy for idiopathic short stature affected the progression of the scoliosis Cobb angle and apical vertebral translation on the coronal plane. Physicians should be aware that annual follow-up is required to evaluate the change in the curvature of the spine in patients undergoing rhGH treatment. © 2017 The Author(s).
DOI
10.1186/s13018-017-0630-z
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의과대학 > 의학과 > Journal papers
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