View : 33 Download: 0

Influence of growth hormone treatment on radiographic indices of the spine: Propensity-matched analysis

Influence of growth hormone treatment on radiographic indices of the spine: Propensity-matched analysis
Yun Y.-H.Kwon S.-S.Koh Y.Kim D.-J.Ahn J.Lee S.Y.
Ewha Authors
Issue Date
Journal Title
Journal of Orthopaedic Surgery and Research
1749-799XJCR Link
vol. 12, no. 1
Growth hormonePropensity-matched analysisScoliosis
BioMed Central Ltd.
Background: We performed this study to investigate the influence of recombinant human growth hormone (rhGH) therapy on radiographic indices of the spine using propensity-matched analysis. Methods: Patients with idiopathic short stature who had undergone both growth hormone therapy and whole-spine radiographs more than twice prior to 15years of age were included in the patient group. Other patients who had undergone whole-spine radiographs more than twice prior to the same age during regular checkups for idiopathic scoliosis formed the control group. Propensity-matched analysis was performed to reduce the selection bias. The scoliosis Cobb angle, coronal balance, apical vertebral translation, apical rotation, and pelvic obliquity were measured from the radiographs taken at the periodic follow-ups. The rate of progression of the measurements was adjusted by multiple factors using a linear mixed model with sex as the fixed effect and age and each subject as the random effects. Results: Using a propensity-matched analysis, 48 patients were finally included in both groups. The scoliosis Cobb angle increased by 1.0° (p<0.001) per year in the patient group, whereas there was no significant annual change in the control group (p=0.496). Female patients showed a greater scoliosis Cobb angle (1.8°, p=0.039) compared with male patients. There was no significant difference between the patient and control groups in coronal balance (p=0.264). Apical vertebral translation per year was increased by 1.2mm (p<0.001) in the patient group and 0.5mm in the control group (p=0.003). Conclusion: Radiographic examination revealed that growth hormone therapy for idiopathic short stature affected the progression of the scoliosis Cobb angle and apical vertebral translation on the coronal plane. Physicians should be aware that annual follow-up is required to evaluate the change in the curvature of the spine in patients undergoing rhGH treatment. © 2017 The Author(s).
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.