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Polycystic ovary morphology is associated with insulin resistance in women with polycystic ovary syndrome

Title
Polycystic ovary morphology is associated with insulin resistance in women with polycystic ovary syndrome
Authors
Hong S.-H.Sung Y.-A.Hong Y.S.Jeong K.Chung H.Lee H.
Ewha Authors
홍영선정경아이혜진
SCOPUS Author ID
홍영선scopus; 정경아scopus; 이혜진scopus
Issue Date
2017
Journal Title
Clinical Endocrinology
ISSN
0300-0664JCR Link
Citation
vol. 87, no. 4, pp. 375 - 380
Keywords
insulin resistancepolycystic ovary morphologypolycystic ovary syndrome
Publisher
Blackwell Publishing Ltd
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background/Objectives: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by chronic anovulation, hyperandrogenism, polycystic ovary morphology (PCOM) and metabolic disturbances including insulin resistance and type 2 diabetes mellitus. Although insulin resistance could be associated with PCOM, recent studies have shown controversial results. The aim of this study was to determine the relationship between PCOM and insulin resistance. Subjects/Methods: This was a cross-sectional clinical study. A total of 679 women with PCOS who were diagnosed using the National Institute of Child Health and Human Disease (NICHD) criteria and 272 control women were analysed. We measured fasting glucose and insulin levels, 75 g oral glucose tolerance test-derived glucose and insulin levels, testosterone levels, ovarian volume and follicle number. Results: Polycystic ovary morphology was described in 543 women (80.0%) with PCOS. Women with PCOS had significantly higher 2 hours postload glucose, fasting and 2 hours postload insulin levels, ovarian volume, ovarian follicle numbers and lower insulin sensitivity compared with those of the controls (all P<.01). In women with PCOS, ovarian volume and ovarian follicle number were negatively associated with the quantitative insulin sensitivity check index after adjusting for age, body mass index and total testosterone; however, this association was not observed in the controls. In the logistic regression analysis, increased ovarian follicle number was associated with decreased insulin sensitivity in women with PCOS. Conclusions: In PCOS, enlarged ovarian volume and follicle excess were associated with insulin resistance, and the number of ovarian follicles could be a predictor of insulin resistance. © 2017 John Wiley & Sons Ltd
DOI
10.1111/cen.13380
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의과대학 > 의학과 > Journal papers
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