Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.contributor.author | 안영호 | * |
dc.date.accessioned | 2017-11-01T05:01:55Z | - |
dc.date.available | 2017-11-01T05:01:55Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-21136 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/239055 | - |
dc.description.abstract | The NFκB family of transcription factors is crucial for innate or adaptive immunity, inflammation, and diseases including cancer. The two NFκB signaling pathways (canonical and non-canonical) differ from each other in extracellular signals, membrane receptors, signaling adaptors, and dimer subunits. The p52 (NFκB2) subunit, which participates in the non-canonical pathway, is generated by ubiquitin-mediated processing of the p100 precursor. Here, we found that NFκB2 processing and activation were mediated by mitogen-activated protein kinase kinase-4 (MKK4) and its substrate c-Jun N-terminal kinase (JNK). In MKK4-null mouse embryonic fibroblasts (MEFs), serum- and lymphotoxin β receptor (LTβR) antibody-induced processing of p100 and nuclear translocation of p52 were found to be defective. Serum and LTβR antibody activated the MKK4-JNK signaling pathway, and SP600125, a JNK inhibitor, blocked p100 processing. Cellular senescence, one of the responses regulated by the non-canonical NFκB pathway, was observed more frequently in MKK4-null MEFs than in wildtype cells. These results suggest that the MKK4/JNK-dependent pathway regulates NFκB2 processing/activation and, through this mechanism, MKK4 and NFκB2 control cellular growth and senescence. © 2017 Elsevier Inc. | * |
dc.language | English | * |
dc.publisher | Elsevier B.V. | * |
dc.subject | c-Jun N-Terminal kinase (JNK) | * |
dc.subject | Mitogen-activated protein kinase kinase-4 (MKK4) | * |
dc.subject | NFκB non-canonical pathway | * |
dc.subject | Senescence | * |
dc.title | MKK4 activates non-canonical NFκB signaling by promoting NFκB2-p100 processing | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 491 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 337 | * |
dc.relation.lastpage | 342 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1016/j.bbrc.2017.07.099 | * |
dc.identifier.wosid | WOS:000408291100015 | * |
dc.identifier.scopusid | 2-s2.0-85025143158 | * |
dc.author.google | Kim J.S. | * |
dc.author.google | Kim E.J. | * |
dc.author.google | Kim H.-S. | * |
dc.author.google | Kurie J.M. | * |
dc.author.google | Ahn Y.-H. | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.contributor.scopusid | 안영호(7202402440) | * |
dc.date.modifydate | 20240222132209 | * |