Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.date.accessioned | 2017-11-01T05:01:53Z | - |
dc.date.available | 2017-11-01T05:01:53Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 2045-2322 | * |
dc.identifier.other | OAK-21092 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/239050 | - |
dc.description.abstract | Toll-like receptor 2 (TLR2) mediates the innate immune response to bacterial lipopeptides and peptidoglycans by stimulating the production of inflammatory cytokines. However, the mechanisms by which TLR2 signaling regulates type I interferon (IFN)-β production are poorly understood. Here, we identified Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) as a negative regulator of TLR2-induced IFN-β production. Pharmacological inhibition or reduced expression of SHP2 potentiated TLR2 agonist-mediated IFN-β transcription and STAT1 activation, whereas overexpression of SHP2 impaired IFN-β transcription and STAT1 activation. SHP2 physically associated with the glycogen synthase kinase 3β (Gsk3β) in an agonist-dependent manner. Gsk3β positively regulates transcription of IFN-β following TLR2 stimulation by inhibiting the phosphorylation of SHP2. SHP2 inhibited the transcriptional activity of IRF-1 and IRF-8 at the IFN-β promoter. Remarkably, IRF-1 and IRF-8 are recruited to the IFN-β promoter in a SHP2 phosphatase activity-dependent manner. These findings provide insight into the mechanisms by which SHP2 and Gsk3β work together to modulate TLR2-mediated IFN-β production in macrophages. © 2017 The Author(s). | * |
dc.language | English | * |
dc.publisher | Nature Publishing Group | * |
dc.title | Reciprocal regulation of TLR2-mediated IFN-β production by SHP2 and Gsk3β | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 7 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Scientific Reports | * |
dc.identifier.doi | 10.1038/s41598-017-07316-3 | * |
dc.identifier.wosid | WOS:000406610000058 | * |
dc.identifier.scopusid | 2-s2.0-85026432561 | * |
dc.author.google | Park J.H. | * |
dc.author.google | Ko R. | * |
dc.author.google | Lee S.Y. | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.date.modifydate | 20240415140424 | * |