View : 17 Download: 1
Gestational age-specific sex difference in mortality and morbidities of preterm infants: A nationwide study
- Gestational age-specific sex difference in mortality and morbidities of preterm infants: A nationwide study
- Shim S.-Y.; Cho S.J.; Kong K.A.; Park E.A.
- Ewha Authors
- 박은애; 조수진; 공경애
- SCOPUS Author ID
- 박은애; 조수진; 공경애
- Issue Date
- Journal Title
- Scientific Reports
- vol. 7, no. 1
- Nature Publishing Group
- SCI; SCIE; SCOPUS
- This study aims to determine whether male sex has adverse effect on mortality and morbidities in very low birth weight infants (VLBWI) <30 weeks of gestation and to ascertain this sex effect, stratified by gestational age, adjusting for perinatal risk factors. This is a population-based study from Korean Neonatal Network for VLBWI born at 23+0 and 29+6 weeks of gestation between January 2013 and December 2014. The primary outcome was gestation-specific sex difference in the occurrence of mortality, combined morbidities, and individual morbidity. A total of 2228 VLBWI were enrolled (males, 51.7%). Mortality was not different between sexes. The risk of bronchopulmonary dysplasia and combined morbidities was significantly higher in males ≤25 weeks of gestation (odds ratio [OR] 2.08, 95% confidence interval [CI] 1.35-3.20 and OR 2.00, CI 1.19-3.39, respectively). Males had a significantly higher incidence of periventricular leukomalacia at 23 and 29 weeks of gestation. The risk of severe retinopathy of prematurity was higher in females >25 weeks of gestation. Although both sexes have similar risk for mortality, male sex remains an independent risk for major morbidities, especially at ≤25 weeks of gestation. The risk of each outcome for males has a specific pattern with increasing gestational age. © 2017 The Author(s).
- Appears in Collections:
- 의학전문대학원 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.