Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김현석 | - |
dc.date.accessioned | 2017-11-01T05:01:42Z | - |
dc.date.available | 2017-11-01T05:01:42Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.other | OAK-20806 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/239011 | - |
dc.description.abstract | Acute pancreatitis (AP) is a complicated disease without specific drug therapy. The cofactor nicotinamide adenine dinucleotide (NAD+) is an important regulator of cellular metabolism and homeostasis. However, it remains unclear whether modulation of NAD+ levels has an impact on caerulein-induced AP. Therefore, in this study, we investigated the effect of increased cellular NAD+ levels on caerulein-induced AP. We demonstrated for the first time that the activities and expression of SIRT1 were suppressed by reduction of intracellular NAD+ levels and the p53-microRNA-34a pathway in caerulein-induced AP. Moreover, we confirmed that the increase of cellular NAD+ by NQO1 enzymatic action using the substrate β-Lapachone suppressed caerulein-induced AP with down-regulating TLR4-mediated inflammasome signalling, and thereby reducing the inflammatory responses and pancreatic cell death. These results suggest that pharmacological stimulation of NQO1 could be a promising therapeutic strategy to protect against pathological tissue damage in AP. © The Author(s) 2017. | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.title | NAD+ augmentation ameliorates acute pancreatitis through regulation of inflammasome signalling | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 7 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | Scientific Reports | - |
dc.identifier.doi | 10.1038/s41598-017-03418-0 | - |
dc.identifier.wosid | WOS:000402879800062 | - |
dc.identifier.scopusid | 2-s2.0-85020479837 | - |
dc.author.google | Shen A. | - |
dc.author.google | Kim H.-J. | - |
dc.author.google | Oh G.-S. | - |
dc.author.google | Lee S.-B. | - |
dc.author.google | Lee S.H. | - |
dc.author.google | Pandit A. | - |
dc.author.google | Khadka D. | - |
dc.author.google | Choe S.-K. | - |
dc.author.google | Kwak S.C. | - |
dc.author.google | Yang S.-H. | - |
dc.author.google | Cho E.-Y. | - |
dc.author.google | Kim H.-S. | - |
dc.author.google | Kim H. | - |
dc.author.google | Park R. | - |
dc.author.google | Kwak T.H. | - |
dc.author.google | So H.-S. | - |
dc.contributor.scopusid | 김현석(57191717681) | - |
dc.date.modifydate | 20230201113042 | - |