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Retrosplenial cortical thinning as a possible major contributor for cognitive impairment in HIV patients
- Title
- Retrosplenial cortical thinning as a possible major contributor for cognitive impairment in HIV patients
- Authors
- Shin, Na-Young; Hong, Jinwoo; Choi, Jun Yong; Lee, Seung-Koo; Lim, Soo Mee; Yoon, Uicheul
- Ewha Authors
- 임수미
- SCOPUS Author ID
- 임수미
- Issue Date
- 2017
- Journal Title
- EUROPEAN RADIOLOGY
- ISSN
- 0938-7994
1432-1084
- Citation
- EUROPEAN RADIOLOGY vol. 27, no. 11, pp. 4721 - 4729
- Keywords
- HIV; Neurocognitive disorders; Grey matter; Atrophy; Magnetic resonance imaging
- Publisher
- SPRINGER
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Objectives To identify brain cortical regions relevant to HIV-associated neurocognitive disorder (HAND) in HIV patients. Methods HIV patients with HAND (n = 10), those with intact cognition (HIV-IC; n = 12), and age-matched, seronegative controls (n = 11) were recruited. All participants were male and underwent 3-dimensional T1-weighted imaging. Both vertex-wise and region of interest (ROI) analyses were performed to analyse cortical thickness. Results Compared to controls, both HIV-IC and HAND showed decreased cortical thickness mainly in the bilateral primary sensorimotor areas, extending to the prefrontal and parietal cortices. When directly comparing HIV-IC and HAND, HAND showed cortical thinning in the left retrosplenial cortex, left dorsolateral prefrontal cortex, left inferior parietal lobule, bilateral superior medial prefrontal cortices, right temporoparietal junction and left hippocampus, and cortical thickening in the left middle occipital cortex. Left retrosplenial cortical thinning showed significant correlation with slower information processing, declined verbal memory and executive function, and impaired fine motor skills. Conclusions This study supports previous research suggesting the selective vulnerability of the primary sensorimotor cortices and associations between cortical thinning in the prefrontal and parietal cortices and cognitive impairment in HIV-infected patients. Furthermore, for the first time, we propose retrosplenial cortical thinning as a possible major contributor to HIV-associated cognitive impairment.
- DOI
- 10.1007/s00330-017-4836-6
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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