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2-Chlorophenyl-substituted benzofuro[3,2-b] pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent

Title
2-Chlorophenyl-substituted benzofuro[3,2-b] pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent
Authors
Magar, Til Bahadur ThapaKadayat, Tara ManLee, Hwa-JongPark, SeojeongBist, GaneshShrestha, AarajanaKwon, YoungjooLee, Eung-Seok
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2017
Journal Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN
0960-894XJCR Link1464-3405JCR Link
Citation
vol. 27, no. 15, pp. 3279 - 3283
Keywords
HeterocyclesBenzofuro[3,2-b] pyridinesChlorine-substituentTopoisomerase I and II inhibitionAntiproliferative activity
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
A new series of 2-chloropheny-substituted benzofuro[3,2-b] pyridines were designed, synthesized, and evaluated for topoisomerase I and II inhibition and antiproliferative activity. Compounds 17-19, 23, 24, 26, and 27 exhibited excellent topo II inhibitory activity. A systematic structure-activity relationship study revealed the important role of chlorine substitution in the strong topoisomerase inhibitory activity. (C) 2017 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2017.06.025
Appears in Collections:
약학대학 > 약학과 > Journal papers
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