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Impact of early diagnosis on functional disability in rheumatoid arthritis

Title
Impact of early diagnosis on functional disability in rheumatoid arthritis
Authors
Kim, DamChoi, Chan-BumLee, JiyoungCho, Soo-KyungWon, SoyoungBang, So-YoungCha, Hoon-SukChoe, Jung-YoonChung, Won TaeHong, Seung-JaeJun, Jae-BumJung, Young OkKim, JinseokKim, Seong-KyuKim, Tae-HwanKim, Tae-JongKoh, EunmiLee, Hye-SoonLee, JaejoonLee, JisooLee, Sang-HeonLee, Shin-SeokLee, Sung WonShim, Seung-CheolYoo, Dae-HyunYoon, Bo YoungSung, Yoon-KyoungBae, Sang-CheolKORONA Investigators
Ewha Authors
이지수
SCOPUS Author ID
이지수scopus
Issue Date
2017
Journal Title
KOREAN JOURNAL OF INTERNAL MEDICINE
ISSN
1226-3303JCR Link2005-6648JCR Link
Citation
vol. 32, no. 4, pp. 738 - 746
Keywords
Early diagnosisDisabilityArthritisrheumatoidHealth assessment questionnaires
Publisher
KOREAN ASSOC INTERNAL MEDICINE
Indexed
SCIE; KCI WOS
Abstract
Background/Aims: To determine whether early diagnosis is beneficial for functional status of various disease durations in rheumatoid arthritis (RA) patients. Methods: A total of 4,540 RA patients were enrolled as part of the Korean Observational Study Network for Arthritis (KORONA). We defined early diagnosis as a lag time between symptom onset and RA diagnosis of <= 12 months, whereas patients with a longer lag time comprised the delayed diagnosis group. Demographic characteristics and outcomes were compared between early and delayed diagnosis groups. Logistic regression analyses were performed to identify the impact of early diagnosis on the development of functional disability in RA patients. Results: A total of 2,597 patients (57.2%) were included in the early diagnosis group. The average Health Assessment Questionnaire-Disability Index (HAQ-DI) score was higher in the delayed diagnosis group (0.64 +/- 0.63 vs. 0.70 +/- 0.66, p < 0.01), and the proportion of patients with no functional disability (HAQ = 0) was higher in the early diagnosis group (22.9% vs. 20.0%, p = 0.02). In multivariable analyses, early diagnosis was independently associated with no functional disability (odds ratio [OR], 1.19; 95% confidence interval [CI], 1.01 to 1.40). In a subgroup analysis according to disease duration, early diagnosis was associated with no functional disability in patients with disease duration < 5 years (OR, 1.37; 95% CI, 1.09 to 1.72) but not in patients with longer disease duration (for 5 to 10 years: OR, 1.07; 95% CI, 0.75 to 1.52; for = 10 years: OR, 0.92; 95% CI, 0.65 to 1.28). Conclusions: Early diagnosis is associated with no functional disability, especially in patients with shorter disease duration.
DOI
10.3904/kjim.2015.364
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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