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dc.contributor.author장남수*
dc.contributor.author김혜숙*
dc.date.accessioned2017-10-27T11:45:14Z-
dc.date.available2017-10-27T11:45:14Z-
dc.date.issued2017*
dc.identifier.issn1976-1457*
dc.identifier.otherOAK-21108*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/237143-
dc.description.abstractBACKGROUND/OBJECTIVES: Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. Homocysteine has been recently identified as a predictor of cardiovascular disease-related complications in diabetes. We investigated whether or not supplementation with folic acid tablets can lower homocysteine levels and improve parameters related with vascular complications. SUBJECTS/METHODS: We conducted a non-randomized 8-week trial involving postmenopausal diabetic women (n = 25) supplemented with 800 μg of folic acid (400 μg twice a day) daily. Subjects’ serum levels of folate, homocysteine, and vitamin B12 were measured, along with vascular function and brachial-ankle pulse wave velocity. RESULTS: Folic acid supplementation significantly increased serum folate levels (P < 0.0001), reduced homocysteine levels (P < 0.0001), and increased vitamin B12 levels (P = 0.0063). There were significant decreases in low-density lipoprotein cholesterol levels as well as the ratios of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol and total cholesterol to high-density lipoprotein cholesterol. Brachial-ankle pulse wave velocities were not altered by supplementation. Changes in serum vitamin B12 after folic acid supplementation were negatively correlated with changes in brachial-ankle pulse wave velocity. CONCLUSIONS: In this study on postmenopausal Korean women with type 2 diabetes mellitus, folic acid supplementation reduced serum homocysteine levels, increased serum folate and vitamin B12 levels, and lowered lipid parameters. © 2017 The Korean Nutrition Society and the Korean Society of Community Nutrition.*
dc.languageEnglish*
dc.publisherKorean Nutrition Society*
dc.subjectFolic acid*
dc.subjectLDL cholesterol*
dc.subjectPulse wave velocity*
dc.subjectVitamin B12*
dc.titleEffects of folic acid supplementation on serum homocysteine levels, lipid profiles, and vascular parameters in post-menopausal Korean women with type 2 diabetes mellitus*
dc.typeArticle*
dc.relation.issue4*
dc.relation.volume11*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.indexKCI*
dc.relation.startpage327*
dc.relation.lastpage333*
dc.relation.journaltitleNutrition Research and Practice*
dc.identifier.doi10.4162/nrp.2017.11.4.327*
dc.identifier.wosidWOS:000407539600008*
dc.identifier.scopusid2-s2.0-85026812175*
dc.author.googleVijayakumar A.*
dc.author.googleKim E.-K.*
dc.author.googleKim H.*
dc.author.googleChoi Y.J.*
dc.author.googleHuh K.B.*
dc.author.googleChang N.*
dc.contributor.scopusid장남수(7202467832;56447965800)*
dc.contributor.scopusid김혜숙(37109742100;57211119775)*
dc.date.modifydate20240220113213*
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신산업융합대학 > 식품영양학과 > Journal papers
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