Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장남수 | * |
dc.contributor.author | 김혜숙 | * |
dc.date.accessioned | 2017-10-27T11:45:14Z | - |
dc.date.available | 2017-10-27T11:45:14Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1976-1457 | * |
dc.identifier.other | OAK-21108 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/237143 | - |
dc.description.abstract | BACKGROUND/OBJECTIVES: Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. Homocysteine has been recently identified as a predictor of cardiovascular disease-related complications in diabetes. We investigated whether or not supplementation with folic acid tablets can lower homocysteine levels and improve parameters related with vascular complications. SUBJECTS/METHODS: We conducted a non-randomized 8-week trial involving postmenopausal diabetic women (n = 25) supplemented with 800 μg of folic acid (400 μg twice a day) daily. Subjects’ serum levels of folate, homocysteine, and vitamin B12 were measured, along with vascular function and brachial-ankle pulse wave velocity. RESULTS: Folic acid supplementation significantly increased serum folate levels (P < 0.0001), reduced homocysteine levels (P < 0.0001), and increased vitamin B12 levels (P = 0.0063). There were significant decreases in low-density lipoprotein cholesterol levels as well as the ratios of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol and total cholesterol to high-density lipoprotein cholesterol. Brachial-ankle pulse wave velocities were not altered by supplementation. Changes in serum vitamin B12 after folic acid supplementation were negatively correlated with changes in brachial-ankle pulse wave velocity. CONCLUSIONS: In this study on postmenopausal Korean women with type 2 diabetes mellitus, folic acid supplementation reduced serum homocysteine levels, increased serum folate and vitamin B12 levels, and lowered lipid parameters. © 2017 The Korean Nutrition Society and the Korean Society of Community Nutrition. | * |
dc.language | English | * |
dc.publisher | Korean Nutrition Society | * |
dc.subject | Folic acid | * |
dc.subject | LDL cholesterol | * |
dc.subject | Pulse wave velocity | * |
dc.subject | Vitamin B12 | * |
dc.title | Effects of folic acid supplementation on serum homocysteine levels, lipid profiles, and vascular parameters in post-menopausal Korean women with type 2 diabetes mellitus | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 327 | * |
dc.relation.lastpage | 333 | * |
dc.relation.journaltitle | Nutrition Research and Practice | * |
dc.identifier.doi | 10.4162/nrp.2017.11.4.327 | * |
dc.identifier.wosid | WOS:000407539600008 | * |
dc.identifier.scopusid | 2-s2.0-85026812175 | * |
dc.author.google | Vijayakumar A. | * |
dc.author.google | Kim E.-K. | * |
dc.author.google | Kim H. | * |
dc.author.google | Choi Y.J. | * |
dc.author.google | Huh K.B. | * |
dc.author.google | Chang N. | * |
dc.contributor.scopusid | 장남수(7202467832;56447965800) | * |
dc.contributor.scopusid | 김혜숙(37109742100;57211119775) | * |
dc.date.modifydate | 20240220113213 | * |