View : 30 Download: 0
The Inhibitory Effect of Tartary Buckwheat Extracts on Adipogenesis and Inflammatory Response
- The Inhibitory Effect of Tartary Buckwheat Extracts on Adipogenesis and Inflammatory Response
- Lee, Mak-Soon; Shin, Yoonjin; Jung, Sunyoon; Kim, Seog-Young; Jo, Young-Hee; Kim, Chong-Tai; Yun, Min-Kyu; Lee, Sung-Jin; Sohn, Johann; Yu, Heui-Jong; Kim, Yangha
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- vol. 22, no. 7
- tartary buckwheat; adipogenesis; inflammatory response; 3T3-L1 adipocytes
- MDPI AG
- SCIE; SCOPUS
- Tartary buckwheat (Fagopyrum tataricum) has been established globally as a nutritionally important food item, particularly owing to high levels of bioactive compounds such as rutin. This study investigated the effect of tartary buckwheat extracts (TBEs) on adipogenesis and inflammatory response in 3T3-L1 cells. TBEs inhibited lipid accumulation, triglyceride content, and glycerol-3-phosphate dehydrogenase (GPDH) activity during adipocyte differentiation of 3T3-L1 cells. The mRNA levels of genes involved in fatty acid synthesis, such as peroxisome proliferator-activated receptor-gamma (PPAR-gamma), CCAAT/enhancer binding protein-alpha (CEBP-alpha), adipocyte protein 2 (aP2), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), and stearoylcoenzyme A desaturase-1 (SCD-1), were suppressed by TBEs. They also reduced the mRNA levels of inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), and inducible nitric oxide synthase (iNOS). In addition, TBEs were decreased nitric oxide (NO) production. These results suggest that TBEs may inhibit adipogenesis and inflammatory response; therefore, they seem to be beneficial as a food ingredient to prevent obesity-associated inflammation.
- Appears in Collections:
- 신산업융합대학 > 식품영양학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.