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The Inhibitory Effect of Tartary Buckwheat Extracts on Adipogenesis and Inflammatory Response

Title
The Inhibitory Effect of Tartary Buckwheat Extracts on Adipogenesis and Inflammatory Response
Authors
Lee, Mak-SoonShin, YoonjinJung, SunyoonKim, Seog-YoungJo, Young-HeeKim, Chong-TaiYun, Min-KyuLee, Sung-JinSohn, JohannYu, Heui-JongKim, Yangha
Ewha Authors
김양하
SCOPUS Author ID
김양하scopus
Issue Date
2017
Journal Title
MOLECULES
ISSN
1420-3049JCR Link
Citation
vol. 22, no. 7
Keywords
tartary buckwheatadipogenesisinflammatory response3T3-L1 adipocytes
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS
Abstract
Tartary buckwheat (Fagopyrum tataricum) has been established globally as a nutritionally important food item, particularly owing to high levels of bioactive compounds such as rutin. This study investigated the effect of tartary buckwheat extracts (TBEs) on adipogenesis and inflammatory response in 3T3-L1 cells. TBEs inhibited lipid accumulation, triglyceride content, and glycerol-3-phosphate dehydrogenase (GPDH) activity during adipocyte differentiation of 3T3-L1 cells. The mRNA levels of genes involved in fatty acid synthesis, such as peroxisome proliferator-activated receptor-gamma (PPAR-gamma), CCAAT/enhancer binding protein-alpha (CEBP-alpha), adipocyte protein 2 (aP2), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), and stearoylcoenzyme A desaturase-1 (SCD-1), were suppressed by TBEs. They also reduced the mRNA levels of inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), and inducible nitric oxide synthase (iNOS). In addition, TBEs were decreased nitric oxide (NO) production. These results suggest that TBEs may inhibit adipogenesis and inflammatory response; therefore, they seem to be beneficial as a food ingredient to prevent obesity-associated inflammation.
DOI
10.3390/molecules22071160
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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