Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박기덕 | * |
dc.contributor.author | 이향운 | * |
dc.contributor.author | 정지향 | * |
dc.date.accessioned | 2017-10-27T11:45:10Z | - |
dc.date.available | 2017-10-27T11:45:10Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1949-2553 | * |
dc.identifier.other | OAK-21194 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/237125 | - |
dc.description.abstract | Objectives: To investigate the diagnostic and prognostic values of cerebrospinal fluid (CSF) CYFRA 21-1 in patients with leptomeningeal carcinomatosis (LMC). Methods: Concentration of CSF CYFRA 21-1 was detected using electro-chemiluminescent immunoassay. The difference in level of CYFRA 21-1 between 61 patients with LMC and 200 patients with other neurological disease was evaluated, and diagnostic performance of CSF CYFRA 21-1 was investigated. In LMC patients treated with ventriculo-lumbar perfusion (VLP) chemotherapy, prognostic performance of CSF CYFRA 21-1 was evaluated. Results: The CSF CYFRA 21-1 was significantly higher in LMC patients than that in patients with other neurological diseases (p<0.001). The sensitivity, specificity, accuracy, and positive and negative predictive values were 80.3%, 95.0%, 91.6%, 83.1%, and 94.1% for CSF CYFRA 21-1, and 65.6%, 100%, 92.0%, 100%, and 90.5% for CSF cytology, respectively. The use of high CSF CYFRA 21-1 and/or positive CSF cytology findings resulted in an increased sensitivity of 85.3%, without compromising specificity. LMC patients with high CSF CYFRA 21-1 were more frequently accompanied by positive CSF cytology results than those with low CSF CYFRA 21-1. The median overall survival was longer in LMC patients with low CSF CYFRA 21-1 than in those with high CSF CYFRA 21-1 (p=0.031). During VLP chemotherapy, the clinical responses were found to be correlated with the biological responses, including the level of CSF CYFRA 21-1 and intracranial pressure. Conclusions: CSF CYFRA 21-1 might be regarded as an additional diagnostic tool for LMC and a potential significant prognostic biomarker in LMC patients treated with VLP chemotherapy. | * |
dc.language | English | * |
dc.publisher | IMPACT JOURNALS LLC | * |
dc.subject | leptomeningeal carcinomatosis | * |
dc.subject | diagnosis | * |
dc.subject | prognosis | * |
dc.subject | CSF | * |
dc.subject | CYFRA 21-1 | * |
dc.title | Diagnostic and prognostic values of cerebrospinal fluid CYFRA 21-1 in patients with leptomeningeal carcinomatosis | * |
dc.type | Article | * |
dc.relation.issue | 32 | * |
dc.relation.volume | 8 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 53326 | * |
dc.relation.lastpage | 53335 | * |
dc.relation.journaltitle | ONCOTARGET | * |
dc.identifier.doi | 10.18632/oncotarget.18405 | * |
dc.identifier.wosid | WOS:000407124100107 | * |
dc.author.google | Hyun, Jae-Won | * |
dc.author.google | Park, Ji Hyun | * |
dc.author.google | Kang, Boo Gil | * |
dc.author.google | Park, Eun Young | * |
dc.author.google | Park, Boram | * |
dc.author.google | Joo, Jungnam | * |
dc.author.google | Kim, Jong Kuk | * |
dc.author.google | Kim, Su-Hyun | * |
dc.author.google | Jeong, Jee Hyang | * |
dc.author.google | Lee, Hyang Woon | * |
dc.author.google | Park, Kee Duk | * |
dc.author.google | Choi, Kyung Gyu | * |
dc.author.google | Hwang, Sang-Hyun | * |
dc.author.google | Gwak, Ho-Shin | * |
dc.author.google | Kim, Ho Jin | * |
dc.contributor.scopusid | 박기덕(8662190800) | * |
dc.contributor.scopusid | 이향운(34667959700) | * |
dc.contributor.scopusid | 정지향(7402045750;57192068764) | * |
dc.date.modifydate | 20240123091326 | * |