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Prefrontal Cortical Thickness Deficit in Detoxified Alcohol-dependent Patients

Title
Prefrontal Cortical Thickness Deficit in Detoxified Alcohol-dependent Patients
Authors
Bae, SujinKang, IlhyangLee, Boung ChulJeon, YujinCho, Han ByulYoon, SujungLim, Soo MeeKim, JungyoonLyoo, In KyoonKim, Jieun E.Choi, Ihn-Geun
Ewha Authors
김지은
SCOPUS Author ID
김지은scopus
Issue Date
2016
Journal Title
EXPERIMENTAL NEUROBIOLOGY
ISSN
1226-2560JCR Link2093-8144JCR Link
Citation
vol. 25, no. 6, pp. 333 - 341
Keywords
AlcoholismCerebral CortexFrontal LobeMagnetic Resonance Imaging
Publisher
KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE
Indexed
KCI WOS
Abstract
Alcohol dependence is a serious disorder that can be related with a number of potential health-related and social consequences. Cortical thickness measurements would provide important information on the cortical structural alterations in patients with alcohol dependence. Twenty-one patients with alcohol dependence and 22 healthy comparison subjects have been recruited and underwent high-resolution brain magnetic resonance (MR) imaging and clinical assessments. T1-weighted MR images were analyzed using the cortical thickness analysis program. Significantly thinner cortical thickness in patients with alcohol dependence than healthy comparison subjects was noted in the left superior frontal cortical region, correcting for multiple comparisons and adjusting with age and hemispheric average cortical thickness. There was a significant association between thickness in the cluster of the left superior frontal cortex and the duration of alcohol use. The prefrontal cortical region may particularly be vulnerable to chronic alcohol exposure. It is also possible that the pre-existing deficit in this region may have rendered individuals more susceptible to alcohol dependence.
DOI
10.5607/en.2016.25.6.333
Appears in Collections:
일반대학원 > 뇌·인지과학과 > Journal papers
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