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Association Between Serum Levels of Uric Acid and Blood Pressure Tracking in Childhood

Title
Association Between Serum Levels of Uric Acid and Blood Pressure Tracking in Childhood
Authors
Park, BohyunLee, Hye AhLee, Sung HeePark, Bo MiPark, Eun AeKim, Hae SoonCho, Su JinPark, Hyesook
Ewha Authors
박은애김혜순박혜숙조수진
SCOPUS Author ID
박은애scopus; 김혜순scopus; 박혜숙scopus; 조수진scopus
Issue Date
2017
Journal Title
AMERICAN JOURNAL OF HYPERTENSION
ISSN
0895-7061JCR Link1941-7225JCR Link
Citation
vol. 30, no. 7, pp. 713 - 718
Keywords
blood pressureearly childhoodhypertensioninterventionlongitudinal blood pressuremonitoringuric acid
Publisher
OXFORD UNIV PRESS
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
BACKGROUND Recent studies suggest that high levels of serum uric acid of very early life are a result of the in-utero environment and may lead to elevated blood pressure (BP) in adulthood. However, serum uric acid levels can change throughout life. We investigated the effect of serum uric acid levels in childhood on the BP tracking and analysed BP according to changes in serum uric acid levels in early life. METHODS A total of 449 children from the Ewha Birth and Growth Cohort study underwent at least 2 follow-up examinations. Data were collected across 3 check-up cycles. Serum uric acid levels, BP, and anthropometric characteristics were assessed at 3, 5, and 7 years of age. RESULTS Children with a serum uric acid level higher than the median values had significantly increased systolic BP (SBP) and diastolic BP at 3 years of age. Baseline serum uric acid levels measured at 3 years of age, significantly affected subsequent BP in the sex and body mass index adjusted longitudinal data analysis (P < 0.05). Considering the changing pattern of serum uric acid over time, subjects with high uric acid levels at both 3 and 5 years of age had the highest SBP at 7 years of age. CONCLUSIONS These findings suggest the importance of maintaining an adequate level of serum uric acids from the early life. Appropriate monitoring and intervention of uric acid levels in a high-risk group can reduce the risk of a future increased BP.
DOI
10.1093/ajh/hpx037
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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