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Regulatory Eosinophils in Inflammation and Metabolic Disorders

Title
Regulatory Eosinophils in Inflammation and Metabolic Disorders
Authors
Yang, Bo-GieSeoh, Ju-YongJang, Myoung Ho
Ewha Authors
서주영
SCOPUS Author ID
서주영scopus
Issue Date
2017
Journal Title
IMMUNE NETWORK
ISSN
1598-2629JCR Link2092-6685JCR Link
Citation
vol. 17, no. 1, pp. 41 - 47
Keywords
EosinophilsAnti-inflammationIL-1R antagonistTh17 cellsIL-4IgA
Publisher
KOREA ASSOC IMMUNOLOGISTS
Indexed
KCI WOS
Abstract
Eosinophils are potent effector cells implicated in allergic responses and helminth infections. Responding to stimuli, they release their granule-derived cytotoxic proteins and are involved in inflammatory processes. However, under homeostatic conditions, eosinophils are abundantly present in the intestine and are constantly in contact with the gut microbiota and maintain the balance of immune responses without inflammation. This situation indicates that intestinal eosinophils have an anti-inflammatory function unlike allergic eosinophils. In support of this notion, some papers have shown that eosinophils have different phenotypes depending on the site of residence and are a heterogeneous cell population. Recently, it was reported that eosinophils in the small intestine and adipose tissue, respectively, contribute to homeostasis of intestinal immune responses and metabolism. Accordingly, in this review, we summarize new functions of eosinophils demonstrated in recent studies and discuss their homeostatic functions.
DOI
10.4110/in.2017.17.1.41
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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