View : 8 Download: 0
Regulatory Eosinophils in Inflammation and Metabolic Disorders
- Regulatory Eosinophils in Inflammation and Metabolic Disorders
- Yang, Bo-Gie; Seoh, Ju-Yong; Jang, Myoung Ho
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- IMMUNE NETWORK
- 1598-2629; 2092-6685
- vol. 17, no. 1, pp. 41 - 47
- Eosinophils; Anti-inflammation; IL-1R antagonist; Th17 cells; IL-4; IgA
- KOREA ASSOC IMMUNOLOGISTS
- Eosinophils are potent effector cells implicated in allergic responses and helminth infections. Responding to stimuli, they release their granule-derived cytotoxic proteins and are involved in inflammatory processes. However, under homeostatic conditions, eosinophils are abundantly present in the intestine and are constantly in contact with the gut microbiota and maintain the balance of immune responses without inflammation. This situation indicates that intestinal eosinophils have an anti-inflammatory function unlike allergic eosinophils. In support of this notion, some papers have shown that eosinophils have different phenotypes depending on the site of residence and are a heterogeneous cell population. Recently, it was reported that eosinophils in the small intestine and adipose tissue, respectively, contribute to homeostasis of intestinal immune responses and metabolism. Accordingly, in this review, we summarize new functions of eosinophils demonstrated in recent studies and discuss their homeostatic functions.
- Appears in Collections:
- 의학전문대학원 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.