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Saccharomonopyrones A–C, new α-pyrones from a marine sediment-derived bacterium Saccharomonospora sp. CNQ-490

Title
Saccharomonopyrones A–C, new α-pyrones from a marine sediment-derived bacterium Saccharomonospora sp. CNQ-490
Authors
Yim C.-Y.Le T.C.Lee T.G.Yang I.Choi H.Lee J.Kang K.-Y.Lee J.S.Lim K.-M.Yee S.-T.Kang H.Nam S.-J.Fenical W.
Ewha Authors
임경민남상집
SCOPUS Author ID
임경민scopus; 남상집scopus
Issue Date
2017
Journal Title
Marine Drugs
ISSN
1660-3397JCR Link
Citation
vol. 15, no. 8
Keywords
Marine natural productsSaccharomonospora sp.α-pyrones
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp. CNQ-490 has yielded three new α-pyrones, saccharomonopyrones A–C (1–3). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry data. Saccharomonopyrone A (1) is the first α-pyrone microbial natural product bearing the ethyl-butyl ether chain in the molecule, while saccharomonopyrones B and C possess unusual 3-methyl and a 6-alkyl side-chain within a 3,4,5,6-tetrasubstituted α-pyrone moiety. Saccharomonopyrone A exhibited weak antioxidant activity using a cation radical scavenging activity assay with an IC50 value of 140 µM. © 2017 by the authors. Licensee MDPI.
DOI
10.3390/md15080239
Appears in Collections:
약학대학 > 약학과 > Journal papers
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