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In vitro skin expansion: Wound healing assessment

Title
In vitro skin expansion: Wound healing assessment
Authors
Prim, Peter M.Kim, Han SuShapiro, Lindsey E.Lee, Jae SungKaan, James H.Jackson, John D.Yoo, James J.Atala, AnthonyLee, Sang Jin
Ewha Authors
김한수
SCOPUS Author ID
김한수scopus
Issue Date
2017
Journal Title
WOUND REPAIR AND REGENERATION
ISSN
1067-1927JCR Link1524-475XJCR Link
Citation
vol. 25, no. 3, pp. 398 - 407
Publisher
WILEY
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
For treatments requiring split-thickness skin grafts, it is preferable to mesh the grafts. This reduces the amount of excised skin and covers more wound area. The mesh technique, however, destroys surface continuity, which results in scarring. Strain-based bioreactors, on the other hand, have successfully expanded split-thickness skin grafts in vitro within a 7-day period, increasing graft coverage. After in vitro expansion, the expanded skin grafts were tested in a porcine full-thickness excisional wound model. Expanded graft take rate was 100%. Volumetric, histologic, and mechanical assessments indicated that expanded grafts were comparable to unexpanded grafts (positive control). While there was considerable variation in expansion (31% to -3.1%), this technique has the potential to enhance the coverage area of skin grafts while reducing or eliminating scarring.
DOI
10.1111/wrr.12550
Appears in Collections:
의과대학 > 의학과 > Journal papers
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