View : 12 Download: 0

Possible benefits from post-mastectomy radiotherapy in nodenegative breast cancer patients: a multicenter analysis in Korea (KROG 14-22)

Title
Possible benefits from post-mastectomy radiotherapy in nodenegative breast cancer patients: a multicenter analysis in Korea (KROG 14-22)
Authors
Park, Hae JinShin, Kyung HwanKim, Jin HoAhn, Seung DoKim, Su SsanKim, Yong BaePark, WonKim, Yeon-JooShin, Hyun SooKim, Jin HeeLee, Sun YoungKim, KyuboPark, Kyung RanJeong, Bae Kwon
Ewha Authors
김규보
SCOPUS Author ID
김규보scopus
Issue Date
2017
Journal Title
ONCOTARGET
ISSN
1949-2553JCR Link
Citation
vol. 8, no. 35, pp. 59800 - 59809
Keywords
breast cancerpost-mastectomy radiotherapyrisk factors
Publisher
IMPACT JOURNALS LLC
Indexed
SCIE; SCOPUS WOS
Abstract
Purpose: This study was performed to identify a subset of patients who may benefit from post-mastectomy radiotherapy (PMRT) among node-negative breast cancer patients. Materials and Methods : We retrospectively reviewed 1,828 patients with pT12N0 breast cancer, treated with mastectomy without PMRT from 2005 to 2010 at 10 institutions. Univariate and multivariate analyses for locoregional recurrence (LRR) and any first recurrence (AFR) were performed according to clinicopathologic factors and biologic subtypes. Results: During a median follow-up period of 5.9 years (range: 0.7-10.4 years), 98 patients developed AFR (39 isolated LRR, 13 LRR with synchronous distant metastasis, and 46 isolated distant metastasis), and 52 patients developed LRR. The 7-year LRR and AFR rates were 3.8% and 6.7%, respectively. Multivariate analysis revealed that age of = 40 years (p< 0.001) and T2 stage (p= 0.013) were independent risk factors for LRR. The 7-year LRR rates were 2.5% with no risk factors, 4.5% with one risk factor, and 12.4% with two risk factors. Multivariate analysis for AFR revealed that age of = 40 years (p< 0.001), T2 stage (p< 0.001), and triple-negative biological subtype (p= 0.045) were independent risk factors for AFR. The 7-year AFR rates were 3.9% with no risk factors, 8.4% with one risk factor, and 15.7% with two to three risk factors. Conclusions: Mastectomy without PMRT is a sufficient local treatment for pT12N0M0 breast cancer. Nevertheless, PMRT might be considered for patients with two or three risk factors, among those of young age, with T2 tumors, and with the triplenegative biological subtype based on LRR and AFR.
DOI
10.18632/oncotarget.16241
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE