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Risk factors associated with treatment refusal in lung cancer

Title
Risk factors associated with treatment refusal in lung cancer
Authors
Suh W.N.Kong K.A.Han Y.Kim S.J.Lee S.H.Ryu Y.J.Lee J.H.Shim S.S.Kim Y.Chang J.H.
Ewha Authors
장중현김유경이진화류연주공경애
SCOPUS Author ID
장중현scopus; 김유경scopus; 이진화scopus; 류연주scopus; 공경애scopus
Issue Date
2017
Journal Title
Thoracic Cancer
ISSN
1759-7706JCR Link
Citation
vol. 8, no. 5, pp. 443 - 450
Keywords
Agecomorbiditylung cancertreatment refusal
Publisher
John Wiley and Sons Inc.
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: The incidence of lung cancer is increasing with longer life expectancy. Refusal of active treatment for cancer is prone to cause patients to experience more severe symptoms and shorten survival. The purpose of this study was to define the factors related to refusal or abandonment of active therapy in lung cancer. Methods: We retrospectively reviewed the data of 617 patients from medical records from 2010 to 2014. Two groups were formed: 149 patients who refused anti-cancer treatment and allowed only palliative care were classified into the non-treatment group, while the remaining 468 who received anti-cancer treatment were classified into the treatment group. Results: The groups differed significantly in age, employment, relationship status, number of offspring, educational status, body mass index, presence of chest and systemic symptoms, Charlson Comorbidity Index, Eastern Cooperative Oncology Group score, and tumor node metastasis stage (P < 0.05). In logistic regression analysis, age (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.07–1.13), educational status lower than high school (OR 1.95, 95% CI 1.2–3.2), no history of surgery (OR 2.29, 95% CI 1.4–3.7), body mass index < 18.5 (OR 2.49, 95% CI 1.3–4.7), and a high Eastern Cooperative Oncology Group score of 3 or 4 (OR 5.02, 95% CI 2.3–10.8) were significant factors for refusal of cancer treatment. Conclusion: Individual factors, such as old age, low educational status, low weight, and poor performance status can influence refusal of cancer treatment in patients with lung cancer, and should be considered prior to consultation with patients. © 2017 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd
DOI
10.1111/1759-7714.12461
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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