View : 9 Download: 0
Asthma-COPD Overlap Shows Favorable Clinical Outcomes Compared to Pure COPD in a Korean COPD Cohort
- Asthma-COPD Overlap Shows Favorable Clinical Outcomes Compared to Pure COPD in a Korean COPD Cohort
- Park, Hye Jung; Byun, Min Kwang; Kim, Hyung Jung; Ahn, Chul Min; Lee, Jin Hwa; Shin, Kyeong-Cheol; Uh, Soo-Taek; Ra, Seung Won; Yoo, Kwang-Ha; Jung, Ki Suck
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
- 2092-7355; 2092-7363
- vol. 9, no. 5, pp. 431 - 437
- Chronic obstructive pulmonary disease; asthma-chronic obstructive pulmonary disease overlap syndrome; disease progression
- KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
- SCIE; SCOPUS; KCI
- Purpose: Comparisons of the characteristics of chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome (ACOS) have been the focus of several studies since the diseases were defined by the Global Initiative for Asthma and Global Initiative for Chronic Obstructive Lung Disease guidelines. However, no consensus is available yet. In this study, we aimed to compare the characteristics of asthma-COPD overlap (ACO) and COPD. Methods: We retrospectively reviewed 1,504 patients with COPD in a Korean COPD Subtype Study cohort. The occurrence of ACO was defined as a positive response to a bronchodilator (an increase in forced expiratory volume in 1 second [FEV1] of 12% and 200 mL). Results: Among 1,504 patients with COPD, 223 (14.8%) were diagnosed with ACO. Men (95.5%) and current smokers (32.9%) were more prevalent in the ACO group compared with the pure COPD group (90.5% and 25.3%, respectively; P=0.015 and P=0.026, respectively). Patients with ACO had a better quality of life (St. George's Respiratory Questionnaire for COPD score=31.0 +/- 18.0 [mean +/- standard deviation]) than those with pure COPD (35.3 +/- 19.1) (P=0.002). Although the prevalence of acute exacerbation was not different between the 2 groups, patients with severe exacerbation required hospital admission significantly more frequently in the pure COPD group than in the ACO group. Patients with ACO showed a higher likelihood of FEV1 recovery than those with pure COPD (P<0.001). Conclusions: We suggest that ACO is characterized by less severe symptoms, and therefore it might lead to rare severe exacerbation and the possibility of lung function recovery.
- Appears in Collections:
- 의학전문대학원 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.