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Asthma-COPD Overlap Shows Favorable Clinical Outcomes Compared to Pure COPD in a Korean COPD Cohort

Title
Asthma-COPD Overlap Shows Favorable Clinical Outcomes Compared to Pure COPD in a Korean COPD Cohort
Authors
Park, Hye JungByun, Min KwangKim, Hyung JungAhn, Chul MinLee, Jin HwaShin, Kyeong-CheolUh, Soo-TaekRa, Seung WonYoo, Kwang-HaJung, Ki Suck
Ewha Authors
이진화
SCOPUS Author ID
이진화scopus
Issue Date
2017
Journal Title
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
ISSN
2092-7355JCR Link2092-7363JCR Link
Citation
vol. 9, no. 5, pp. 431 - 437
Keywords
Chronic obstructive pulmonary diseaseasthma-chronic obstructive pulmonary disease overlap syndromedisease progression
Publisher
KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
Purpose: Comparisons of the characteristics of chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome (ACOS) have been the focus of several studies since the diseases were defined by the Global Initiative for Asthma and Global Initiative for Chronic Obstructive Lung Disease guidelines. However, no consensus is available yet. In this study, we aimed to compare the characteristics of asthma-COPD overlap (ACO) and COPD. Methods: We retrospectively reviewed 1,504 patients with COPD in a Korean COPD Subtype Study cohort. The occurrence of ACO was defined as a positive response to a bronchodilator (an increase in forced expiratory volume in 1 second [FEV1] of 12% and 200 mL). Results: Among 1,504 patients with COPD, 223 (14.8%) were diagnosed with ACO. Men (95.5%) and current smokers (32.9%) were more prevalent in the ACO group compared with the pure COPD group (90.5% and 25.3%, respectively; P=0.015 and P=0.026, respectively). Patients with ACO had a better quality of life (St. George's Respiratory Questionnaire for COPD score=31.0 +/- 18.0 [mean +/- standard deviation]) than those with pure COPD (35.3 +/- 19.1) (P=0.002). Although the prevalence of acute exacerbation was not different between the 2 groups, patients with severe exacerbation required hospital admission significantly more frequently in the pure COPD group than in the ACO group. Patients with ACO showed a higher likelihood of FEV1 recovery than those with pure COPD (P<0.001). Conclusions: We suggest that ACO is characterized by less severe symptoms, and therefore it might lead to rare severe exacerbation and the possibility of lung function recovery.
DOI
10.4168/aair.2017.9.5.431
Appears in Collections:
의과대학 > 의학과 > Journal papers
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