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Heme oxygenase-1 induction and anti-inflammatory actions of atractylodes macrocephala and taraxacum herba extracts prevented colitis and was more effective than sulfasalazine in preventing relapse

Title
Heme oxygenase-1 induction and anti-inflammatory actions of atractylodes macrocephala and taraxacum herba extracts prevented colitis and was more effective than sulfasalazine in preventing relapse
Authors
Han K.-H.Park J.-M.Jeong M.Han Y.-M.Go E.-J.Park J.Kim H.Han J.G.Kwon O.Hahm K.B.
Ewha Authors
권오란
SCOPUS Author ID
권오란scopus
Issue Date
2017
Journal Title
Gut and Liver
ISSN
1976-2283JCR Link
Citation
vol. 11, no. 5, pp. 655 - 666
Keywords
Atractylodes macrocephalaInflammationInflammatory bowel diseaseRegenerationTaraxacum herba
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Background/Aims: In inflammatory bowel disease (IBD), repeated bouts of remission and relapse occur in patients and can impose a risk of colitis-Associated cancer. We hypothesized that plant extracts of Atractylodes macrocephala (AM) or Taraxacum herba (TH) may be better than sulfasalazine for treating this disease because these extracts can promote additional regeneration. Methods: Murine intestinal epithelial IEC-6 cells were pretreated with AM or TH before a lipopolysaccharide (LPS)-induced challenge. Acute colitis was induced with 7 days of dextran sulfate sodium (DSS) in male C57BL/6 mice, and extracts of AM and TH were administered for 2 weeks before DSS administration. Results: In vitro studies demonstrated that AM or TH treatment reduced LPS-induced COX-2 and tumor necrosis factor-α mRNA levels but increased heme oxygenase-1 (HO-1). Oral preadministration of AM and TH rescued mice from DSS-induced colitis by inhibiting inflammatory mediators via inactivated extracellular signal regulated kinase and repressed nuclear factor κB and signal transducer and activator of transcription 3, but the effect was weaker for sulfasalazine than that for the extracts. Anti-inflammatory activities occurred via the inhibition of macrophage and T lymphocyte infiltrations. Unlike sulfasalazine, which did not induce HO-1, TH extracts afforded significant HO-1 induction. Conclusions: Because the AM or TH extracts were far superior in preventing DSS-induced colitis than sulfasalazine, AM or TH extracts can be considered natural agents that can prevent IBD relapse.
DOI
10.5009/gnl16496
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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