Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.date.accessioned | 2017-10-27T11:18:31Z | - |
dc.date.available | 2017-10-27T11:18:31Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0257-2753 | * |
dc.identifier.other | OAK-20359 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/236996 | - |
dc.description.abstract | Background: The increased risk of gallstone has been reported in patients with ATP-binding cassette (ABC) transporter polymorphism. The half-transporters ABCG5 and ABCG8 mediate the efflux of cholesterol in hepatocytes and the intestine. We investigated whether ceramide plays a role in cholesterol efflux through the ABC transporters. Methods: Six-week-old C57BL/6J mice were assigned to 3 groups. The normal group (n = 5) was fed a normal chow diet, the cholesterol group (n = 10) was fed a lithogenic diet, and the myriocin group (n = 15) was fed the lithogenic diet and myriocin, a specific inhibitor of serine-palmitoyl transferase. After 6 weeks, the ABCG5 and ABCG8 transporters were analyzed. Results: The rate of cholesterol gallstone formation in cholesterol group was also higher than that in normal and myriocin groups (0, 70, and 40%, respectively). ABCG5 and ABCG8 mRNA levels were significantly increased in cholesterol group and less increased in myriocin group, relative to that in normal group (p < 0.05). Conclusions: The inhibition of ceramide biosynthesis by myriocin suppressed gallstone formation and ABCG5/8 mRNA expression. We expect that ceramide's role as a regulator of the ABCG5/8 transporter might be linked to cholesterol gallstone formation. © 2017 S. Karger AG, Basel. Copyright: All rights reserved. | * |
dc.language | English | * |
dc.publisher | S. Karger AG | * |
dc.subject | ATP-binding cassette transporter G5 | * |
dc.subject | ATP-binding cassette transporter G8 | * |
dc.subject | Ceramide | * |
dc.title | Inhibition of Ceramide Decreased the Expression of ATP-Binding Cassette Transporter G5/8 mRNA in an Animal Model of Cholesterol Gallstone | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 35 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 439 | * |
dc.relation.lastpage | 443 | * |
dc.relation.journaltitle | Digestive Diseases | * |
dc.identifier.doi | 10.1159/000465517 | * |
dc.identifier.wosid | WOS:000407921900003 | * |
dc.identifier.scopusid | 2-s2.0-85015649390 | * |
dc.author.google | Kim H.J. | * |
dc.author.google | Kim J.S. | * |
dc.author.google | Oh S. | * |
dc.author.google | Yoo H.-S. | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.date.modifydate | 20240118133340 | * |