View : 102 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author김영주-
dc.contributor.author곽혜선-
dc.date.accessioned2017-10-27T11:18:31Z-
dc.date.available2017-10-27T11:18:31Z-
dc.date.issued2017-
dc.identifier.issn0031-6970-
dc.identifier.issn1432-1041-
dc.identifier.otherOAK-20445-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/236995-
dc.description.abstractPurpose As a tocolytic agent, ritodrine has been used in European and Asian countries but has lost popularity due to safety concerns. This study aimed to investigate the relationship between adverse drug events caused by ritodrine and the CACNA1C polymorphisms in preterm labor patients. Methods Data were collected from medical records including maternal age, gestational age, body mass index, dilation score, effacement score, modified Bishop score, maximum infusion rate, and adverse drug events. Five single-nucleotide polymorphisms of the CACNA1C gene (rs10774053, rs215994, rs215976, rs2239128, and rs2041135) were analyzed. Results One hundred eighty-six patients were included, 33 of whom had adverse drug events. A allele carriers of rs10774053 showed about 0.293-fold lower adverse drug events than GG genotype carriers (p = 0.012, absolute risk reduction = 16.5%) after adjusting for other confounding variables; the number needed to genotype for preventing one patient with GG genotype from suffering higher incidence of adverse drug events was calculated to be 14.6. Increase in maximum infusion rate of 1 mL/h was associated with a 1.03-fold (95% CI 1.01 similar to 1.06, p = 0.005) increased risk of adverse drug events. None of the patients with a CC genotype of rs215994 had adverse drug events, whereas 22.1% of the T allele carriers had adverse drug events. Conclusion This study showed that CACNA1C gene polymorphisms could alter the probability of adverse drug event risk when ritodrine is used in preterm labor.-
dc.languageEnglish-
dc.publisherSPRINGER HEIDELBERG-
dc.subjectRitodrine-
dc.subjectCACNA1C-
dc.subjectPolymorphism-
dc.subjectAdverse drug events-
dc.subjectPreterm labor patients-
dc.titleAssociation between CACNA1C gene polymorphisms and ritodrine-induced adverse events in preterm labor patients-
dc.typeArticle-
dc.relation.issue7-
dc.relation.volume73-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage837-
dc.relation.lastpage842-
dc.relation.journaltitleEUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY-
dc.identifier.doi10.1007/s00228-017-2222-6-
dc.identifier.wosidWOS:000405666100006-
dc.identifier.scopusid2-s2.0-85017184765-
dc.author.googleBaek, Min Young-
dc.author.googleHwang, Han Sung-
dc.author.googlePark, Jin Young-
dc.author.googleChung, Jee Eun-
dc.author.googleLee, Kyung Eun-
dc.author.googleLee, Gwan Yung-
dc.author.googleSeong, Jin Won-
dc.author.googleYee, Jeong-
dc.author.googleKim, Young Ju-
dc.author.googleGwak, Hye Sun-
dc.contributor.scopusid김영주(55801681000)-
dc.contributor.scopusid곽혜선(6601996377)-
dc.date.modifydate20190901081003-
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE