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Association between CACNA1C gene polymorphisms and ritodrine-induced adverse events in preterm labor patients

Title
Association between CACNA1C gene polymorphisms and ritodrine-induced adverse events in preterm labor patients
Authors
Baek, Min YoungHwang, Han SungPark, Jin YoungChung, Jee EunLee, Kyung EunLee, Gwan YungSeong, Jin WonYee, JeongKim, Young JuGwak, Hye Sun
Ewha Authors
김영주곽혜선
SCOPUS Author ID
김영주scopus; 곽혜선scopus
Issue Date
2017
Journal Title
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
ISSN
0031-6970JCR Link1432-1041JCR Link
Citation
vol. 73, no. 7, pp. 837 - 842
Keywords
RitodrineCACNA1CPolymorphismAdverse drug eventsPreterm labor patients
Publisher
SPRINGER HEIDELBERG
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Purpose As a tocolytic agent, ritodrine has been used in European and Asian countries but has lost popularity due to safety concerns. This study aimed to investigate the relationship between adverse drug events caused by ritodrine and the CACNA1C polymorphisms in preterm labor patients. Methods Data were collected from medical records including maternal age, gestational age, body mass index, dilation score, effacement score, modified Bishop score, maximum infusion rate, and adverse drug events. Five single-nucleotide polymorphisms of the CACNA1C gene (rs10774053, rs215994, rs215976, rs2239128, and rs2041135) were analyzed. Results One hundred eighty-six patients were included, 33 of whom had adverse drug events. A allele carriers of rs10774053 showed about 0.293-fold lower adverse drug events than GG genotype carriers (p = 0.012, absolute risk reduction = 16.5%) after adjusting for other confounding variables; the number needed to genotype for preventing one patient with GG genotype from suffering higher incidence of adverse drug events was calculated to be 14.6. Increase in maximum infusion rate of 1 mL/h was associated with a 1.03-fold (95% CI 1.01 similar to 1.06, p = 0.005) increased risk of adverse drug events. None of the patients with a CC genotype of rs215994 had adverse drug events, whereas 22.1% of the T allele carriers had adverse drug events. Conclusion This study showed that CACNA1C gene polymorphisms could alter the probability of adverse drug event risk when ritodrine is used in preterm labor.
DOI
10.1007/s00228-017-2222-6
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의과대학 > 의학과 > Journal papers
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