View : 4 Download: 0

Percentage change of primary tumor on 18 F-FDG PET/CT as a prognostic factor for invasive ductal breast cancer with axillary lymph node metastasis

Title
Percentage change of primary tumor on 18 F-FDG PET/CT as a prognostic factor for invasive ductal breast cancer with axillary lymph node metastasis
Authors
Yoo J.Kim B.S.Chung J.Yoon H.-J.
Ewha Authors
김범산
SCOPUS Author ID
김범산scopus
Issue Date
2017
Journal Title
Medicine (United States)
ISSN
0025-7974JCR Link
Citation
vol. 96, no. 31
Keywords
diffusion weighted imagingdual time point 18 F-FDG PET/CTdynamic contrastinvasive ductal breast cancermagnetic resonance imagingrecurrence-free survival
Publisher
Lippincott Williams and Wilkins
Indexed
SCI; SCIE; SCOPUS scopus
Abstract
We evaluated the prognostic value of quantitative parameters using dual time point (DTP) 18 F-FDG PET/CT (PET/CT) in invasive ductal breast cancer (IDC) with metastatic axillary lymph nodes (ALN) as compared with dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) MRI. Seventy patients with IDC and metastatic ALN were retrospectively registered. Static PET parameters including maximum standardized uptake value (SUV max), metabolic tumor volume (MTV), total lesion glycolysis (TLG) of primary tumor, SUV max of ALN (SUV ALN), and percentage changes (Δ%) in those parameters were measured with DTP PET/CT. From DCE MRI, peak enhancement value, total tumor angio volume, and proportions of kinetic curve types on delayed-phases were investigated. The average apparent diffusion coefficient (ADC avg) was estimated on DWI. To demonstrate the prognostic value of quantitative imaging parameters for recurrence-free survival (RFS), univariate and multivariate analyses were performed using those parameters and clinicohistologic variables. All static PET parameters, %ΔSUV max, %ΔMTV, and %ΔSUV ALN on DTP PET/CT and ADC avg on DWI were significantly predictive for disease recurrence. Of clinicohistologic variables, pathologic tumor (pT) diameter, pathologic ALN stage, tumor grade, and hormonal status also were significantly prognostic. After multivariate analysis, %ΔSUV max > 25.05 (P =.043), ADC avg ≤ 1016.55 (P =.020), pT diameter > 3 cm (P =.001), and ER negative status (P =.002) were independent prognostic factors for poor outcome. Only %ΔSUV max of the primary tumor on PET/CT together with ADC avg, pT diameter, and ER status was an independent prognostic factor for predicting relapse in IDC with metastatic ALN. Percentage change of primary tumor on preoperative PET/CT may be a valuable imaging marker for selecting IDC patients that require adjunct treatment to prevent relapse. © 2017 the Author(s). Published by Wolters Kluwer Health, Inc.
DOI
10.1097/MD.0000000000007657
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE