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Chiro-Optical Modulation for NURR1 Production from Stem Cells

Title
Chiro-Optical Modulation for NURR1 Production from Stem Cells
Authors
Patel M.Moon H.J.Hong J.H.Jeong B.
Ewha Authors
정병문
SCOPUS Author ID
정병문scopus
Issue Date
2017
Journal Title
ACS Chemical Neuroscience
ISSN
1948-7193JCR Link
Citation
vol. 8, no. 7, pp. 1455 - 1458
Keywords
light emitting diodeneuronal differentiationNURR1polarized light
Publisher
American Chemical Society
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Nuclear receptor related 1 (NURR1) is an essential protein for maintenance of dopaminergic neurons in adult midbrain of which deficiency leads to Parkinson's disease. To enhance the NURR1 production of neural cells, various approaches are under investigation. Here we report that NURR1 is highly expressed in stem cells by exposure to an L-polarized blue light emitting diode (LED). Compared to stem cells cultured in the absence of a LED, under polarized green and red LEDs, the stem cells exposed to a polarized blue LED significantly enhanced neuronal biomarkers such as neurofilament M (NFM) and neuron specific enolase (NSE) at both mRNA and protein levels. In particular, NURR1 was selectively enhanced by the stem cells exposed to the L-polarized blue LED. Stem cells exposed to the L-polarized blue LED increased mitochondrial ATP and intracellular calcium ions, which support neuronal differentiation of the stem cells. This study suggests that chiro-optical treatments by using polarized light with a specific wavelength can be used for engineering of stem cells with enhanced specific biochemicals, which may open a new method for a specific disease. © 2017 American Chemical Society.
DOI
10.1021/acschemneuro.7b00136
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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