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Differentiation between polycystic ovary syndrome and polycystic ovarian morphology by means of an anti-Müllerian hormone cutoff value

Title
Differentiation between polycystic ovary syndrome and polycystic ovarian morphology by means of an anti-Müllerian hormone cutoff value
Authors
Song D.K.Oh J.-Y.Lee H.Sung Y.-A.
Ewha Authors
성연아오지영이혜진
SCOPUS Author ID
성연아scopus; 오지영scopus; 이혜진scopus
Issue Date
2017
Journal Title
Korean Journal of Internal Medicine
ISSN
1226-3303JCR Link
Citation
vol. 32, no. 4, pp. 690 - 698
Keywords
Anti-Mullerian hormoneOvarian cystsPolycystic ovary syndrome
Publisher
Korean Association of Internal Medicine
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Background/Aims: Although increased serum anti-Müllerian hormone (AMH) level has been suggested to be a surrogate marker of polycystic ovarian morphology (PCOM), its association with polycystic ovary syndrome (PCOS) is controversial, and its diagnostic value has not been determined. We aimed to observe the relationship between the AMH level and PCOS phenotypes and to determine the optimal cutoff value of AMH for the diagnosis of PCOS in young Korean women. Methods: We recruited 207 women with PCOS (120 with PCOM and 87 without PCOM) and 220 regular cycling women with normoandrogenemia (100 with PCOM and 120 without PCOM). Subjects underwent testing at a single outpatient visit. Serum AMH level was measured. Results: Women with PCOS had higher serum AMH levels than did regular cycling women with normoandrogenemia (p < 0.05). Women with PCOM had higher serum AMH levels than women without PCOM, regardless of PCOS status (p < 0.05). The optimal AMH cutoff value for the diagnosis of PCOS was 10.0 ng/mL (71% sensitivity, 93% specificity). Serum AMH was an independent determinant of total testosterone after adjustment for age, body mass index, and the number of menses/year (β = 0.31, p < 0.01). An association between AMH and hyperandrogenism was only observed in women with PCOS, and it was independent of the presence of PCOM. Conclusion: The serum AMH level can be useful for the diagnosis of PCOS at any age less than 40 years, and the optimal cutoff value for the diagnosis of PCOS identified in this study of young Korean women was 10.0 ng/mL. © 2017 The Korean Association of Internal Medicine.
DOI
10.3904/kjim.2016.038
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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