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Blood cadmium and volume of uterine fibroids in premenopausal women

Title
Blood cadmium and volume of uterine fibroids in premenopausal women
Authors
Ye S.Chung H.W.Jeong K.Sung Y.-A.Lee H.Park S.Y.Kim H.Ha E.-H.
Ewha Authors
하은희
SCOPUS Author ID
하은희scopus
Issue Date
2017
Journal Title
Annals of Occupational and Environmental Medicine
ISSN
2052-4374JCR Link
Citation
vol. 29, no. 1
Keywords
Heavy metalsPremenopausal womenUterine fibroids
Publisher
BioMed Central Ltd.
Indexed
SCOPUS scopus
Abstract
Background: A number of studies have found associations between heavy metals and uterine fibroids, but the results are inconsistent. Here, we conducted this research to demonstrate the relationships between blood heavy metal concentrations and uterine fibroid volume as well as the rate of uterine fibroid presence. Methods: In a cross-sectional study, we collected data from 308 premenopausal women aged 30-49 years in Seoul; uterine fibroids are ascertained by past history of myomectomy and pelvic ultrasonography. In the analytic phase, we first analyzed the presence of the fibroids and the concentrations of heavy metals via logistic regression. In subgroup analysis, we used simple and multiple linear regression analyses to examine the associations between heavy metals and uterine fibroid volume. Results: There was no connection between the heavy metal concentrations and the presence of uterine fibroids, but the odds of women having fibroids were higher with three particular metals. In subgroup analysis, the association between blood cadmium concentrations and uterine fibroid volume was statistically significant (adjusted beta coefficient = 2.22, 95% confidential interval: 0.06-4.37). In contrast, blood mercury and lead concentrations were not significantly associated with uterine fibroid volume. Conclusions: Our findings are the first that we know to report the association of blood cadmium concentrations with the volume of uterine fibroids. We expect that our findings will be used as evidence for supporting policies to improve premenopausal Korean women's health. © 2017 The Author(s).
DOI
10.1186/s40557-017-0178-8
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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