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Highly Efficient One-Pot Solvent-Free Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazole via BTI-mediated Oxidation of N-Acylhydrazone from Hydrazide and Aldehyde

Title
Highly Efficient One-Pot Solvent-Free Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazole via BTI-mediated Oxidation of N-Acylhydrazone from Hydrazide and Aldehyde
Authors
Yan X.Lee G.Noh K.T.Lee H.Kim H.Lee K.H.Hur N.H.Lee B.Park Y.J.
Ewha Authors
박영준
Issue Date
2017
Journal Title
Bulletin of the Korean Chemical Society
ISSN
0253-2964JCR Link
Citation
vol. 38, no. 7, pp. 723 - 727
Keywords
1,3,4-OxadiazoleBall-millN-AcylhydrazoneSolvent-free[Bis(trifluoroacetoxy)iodo]benzene-oxidation
Publisher
Wiley Blackwell
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
2,5-Disubstituted-1,3,4-oxadiazoles are prepared in excellent yields (up to 97%) under totally solvent-free conditions by the quantitative formation of N-acylhydrazone from the reaction of a hydrazide with an aldehyde using a ball-mill for 10 min at room temperature followed by oxidation with BTI at 80°C for 1h. © 2017 Korean Chemical Society, Seoul & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI
10.1002/bkcs.11160
Appears in Collections:
ETC > ETC
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