Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김선종 | * |
dc.contributor.author | 김진우 | * |
dc.contributor.author | 박정현 | * |
dc.date.accessioned | 2017-08-25T05:08:16Z | - |
dc.date.available | 2017-08-25T05:08:16Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0278-2391 | * |
dc.identifier.issn | 1531-5053 | * |
dc.identifier.other | OAK-20933 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/235729 | - |
dc.description.abstract | Purpose: To investigate the effect of the addition of bone morphogenetic protein 2 (BMP-2) to leukocyte-rich and platelet-rich fibrin (L-PRF) on the treatment of medication-related osteonecrosis of the jaws (MRONJ), this study compared the healing outcome of combined use of BMP-2 and L-PRF with single use of L-PRF. Patients and Methods: Of 55 patients who were diagnosed with MRONJ, 25 were treated with L-PRF alone and 30 were treated with L-PRF and recombinant human BMP-2. For each patient, surgical sites were evaluated postoperatively at 4 and 16 weeks. Associations between the treatment method and the resolution of MRONJ were analyzed with the adjustment of patient-specific factors that may influence the treatment outcome. Results: At 4 and 16 weeks postoperatively, patients with MRONJ who were treated with both L-PRF and BMP-2 showed favorable outcomes with complete resolution of the lesions, which was statistically significant compared with that of the therapy using L-PRF alone (P = .028). Therefore, the additional use of BMP-2 considerably improved MRONJ healing. Among patient-specific factors, the existence of a bacterial colony in the biopsy specimen was a significant factor that negatively affected disease resolution (P = .017). Conclusions: The combined use of BMP-2 and L-PRF leads to the early resolution of MRONJ; thus patients who need to continue antiresorptive therapy may benefit from the combined regimen. (C) 2016 American Association of Oral and Maxillofacial Surgeons | * |
dc.language | English | * |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | * |
dc.title | Does the Addition of Bone Morphogenetic Protein 2 to Platelet-Rich Fibrin Improve Healing After Treatment for Medication-Related Osteonecrosis of the Jaw? | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 75 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1176 | * |
dc.relation.lastpage | 1184 | * |
dc.relation.journaltitle | JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | * |
dc.identifier.doi | 10.1016/j.joms.2016.12.005 | * |
dc.identifier.wosid | WOS:000405092200018 | * |
dc.identifier.scopusid | 2-s2.0-85011072434 | * |
dc.author.google | Park, Jung-Hyun | * |
dc.author.google | Kim, Jin-Woo | * |
dc.author.google | Kim, Sun-Jong | * |
dc.contributor.scopusid | 김선종(55864004900) | * |
dc.contributor.scopusid | 김진우(55333003000) | * |
dc.contributor.scopusid | 박정현(57192816120) | * |
dc.date.modifydate | 20240304131236 | * |